50788
2,5-Hexanediol 3 M solution
Synonym(s):
2,5-Hexanediol solution, Additive Screening Solution 06/Kit-No 78374
InChI
1S/C6H14O2/c1-5(7)3-4-6(2)8/h5-8H,3-4H2,1-2H3
SMILES string
CC(O)CCC(C)O
InChI key
OHMBHFSEKCCCBW-UHFFFAOYSA-N
storage temp.
2-8°C
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
10 - Combustible liquids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter
Regulatory Information
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A K Agrawal et al.
Neurotoxicology, 6(3), 53-59 (1985-01-01)
Single exposure of 150, 300 and 600 mg/kg 2,5-hexanediol, (2,5 HD) a metabolite of n-hexane showed no significant effect on 3H-spiroperidol binding to corpus striatal membranes when compared with control animals, where as repeated exposure of 2,5-HD, 300 and 600
On the pattern of changes in the rat nervous system produced by 2,5 hexanediol. A topographical study by light microscopy.
J B Cavanagh et al.
Brain : a journal of neurology, 104(2), 297-318 (1981-06-01)
S K Goel et al.
Xenobiotica; the fate of foreign compounds in biological systems, 17(2), 217-222 (1987-02-01)
The effect of n-hexane and its metabolite, 2,5-hexanediol, on the haemopoietic system has been investigated in the rat. 59Fe uptake was decreased in the bone marrow of n-hexane-treated animals. Spleen and bone marrow were the target sites for the metabolite
T Yasui et al.
Sangyo eiseigaku zasshi = Journal of occupational health, 37(1), 19-24 (1995-01-01)
Rats were injected subcutaneously with 2,5-hexanedione (2,5-HD 2.6 m mol/kg) alone (HD group) or with 2,5-HD and methyl ethyl ketone (MEK) (2.6 m mol/kg of each agent, HD&MEK group) or with 2,5-HD 2.6 m mol/kg and 5 times that dose
H B Jones et al.
Acta neuropathologica, 58(4), 286-290 (1982-01-01)
Rats were given 2,5-hexanediol, a metabolite of n-hexane, in the drinking water until they developed a marked degree of paresis over about 7 weeks and were then allowed to recover naturally. The time course and the manner of removal of
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