51349
5′-Thiol modifier C6 S-S
≥95.0% (NMR)
Synonym(s):
O-(Dimethoxytrityloxy-hexyl-dithiohexyl)-O′-(2-cyanoethyl)-N,N-diisopropyl-phosphoramidite
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About This Item
Empirical Formula (Hill Notation):
C42H61N2O5PS2
Molecular Weight:
769.05
UNSPSC Code:
12352200
PubChem Substance ID:
MDL number:
SMILES string
COc1ccc(cc1)C(OCCCCCCSSCCCCCCOP(OCCC#N)N(C(C)C)C(C)C)(c2ccccc2)c3ccc(OC)cc3
assay
≥95.0% (NMR)
storage temp.
−20°C
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Other Notes
Modifying agent for 5′-position of nucleosides
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H Gao et al.
Nucleic acids research, 23(2), 285-292 (1995-01-25)
A convenient, practical route to the synthesis of disulfide-bridged oligonucleotides has been developed. Aliphatic linkers with terminal thiol groups have been attached to the phosphodiester backbones of partially or fully complementary oligonucleotide sequences and oxidized to yield covalently closed oligonucleotides
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