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53340

L-Histidine dihydrochloride

≥99.0% (AT)

Synonym(s):

L-Histidine hydrochloride (1:2)

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About This Item

Empirical Formula (Hill Notation):
C6H9N3O2 · 2HCl
CAS Number:
6027-02-7
Molecular Weight:
228.08
NACRES:
NA.26
PubChem Substance ID:
57651406
UNSPSC Code:
12352209
EC Number:
227-890-5
MDL number:
MFCD00066569
Beilstein/REAXYS Number:
6119230
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Product Name

L-Histidine dihydrochloride, ≥99.0% (AT)

Quality Level

100

assay

≥99.0% (AT)

form

powder or crystals

optical activity

[α]20/D +6.5±1°, c = 8% in H2O

ign. residue

≤0.1% (as SO4)

color

white

mp

240-245 °C (dec.)

solubility

H2O: soluble, saline: soluble

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

As: ≤0.1 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, NH4+: ≤500 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

SMILES string

Cl.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

InChI

1S/C6H9N3O2.2ClH/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);2*1H/t5-;;/m0../s1

InChI key

XEJCDBUNISUVGZ-XRIGFGBMSA-N

Related Categories

Biochem/physiol Actions

L-Histidine is a natural proteinogenic α amino acid useful as a cell growth supplement that support protein and peptide biosynthesis. L-Histidine is studied in a wide range of applications that involve imidazole chemistry and biochemisty.
L-Histidine is a positively charged imidazole-side chain containing α amino acid. It is metabolized to histamine and is a precursor of the dipeptide carnosine. As one of the 22 proteinogenic amino acids L-His is incorporated into proteins by translation processes in vitro. L-Histidine is an essential amino acid added to cell culture media.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL4877
BCCJ7513
BCCJ5666
BCCC3647
BCBW3200

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Jorge A Vila et al.
Proceedings of the National Academy of Sciences of the United States of America, 108(14), 5602-5607 (2011-03-23)
A method is proposed to determine the fraction of the tautomeric forms of the imidazole ring of histidine in proteins as a function of pH, provided that the observed and chemical shifts and the protein structure, or the fraction of
Azzurra Stefanucci et al.
International journal of molecular sciences, 12(5), 2853-2890 (2011-06-21)
A successful design of peptidomimetics must come to terms with χ-space control. The incorporation of χ-space constrained amino acids into bioactive peptides renders the χ(1) and χ(2) torsional angles of pharmacophore amino acids critical for activity and selectivity as with
Ana Reis et al.
Analytical and bioanalytical chemistry, 399(8), 2779-2794 (2011-02-01)
The radical oxidation of isomeric peptides containing one reactive amino acid [histidine (H)] and another less reactive amino acid [glycine (G)] in the form of dipeptides (HG and GH) and tripeptides (HGG, GHG, and GGH) was studied by mass spectrometry
Amir Abbas Farshid et al.
Indian journal of pharmacology, 45(2), 126-129 (2013-05-30)
Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C
Kirsten Jung et al.
Current opinion in microbiology, 15(2), 118-124 (2011-12-17)
Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how
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Global Trade Item Number

SKUGTIN
493155-1G04061826664407
53340-10G04061832719320
53340-50G04061832559193

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