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Merck
CN

53340

L-Histidine dihydrochloride

≥99.0% (AT)

Synonym(s):

L-Histidine hydrochloride (1:2)

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About This Item

Empirical Formula (Hill Notation):
C6H9N3O2 · 2HCl
CAS Number:
6027-02-7
Molecular Weight:
228.08
NACRES:
NA.26
PubChem Substance ID:
57651406
UNSPSC Code:
12352209
EC Number:
227-890-5
MDL number:
MFCD00066569
Beilstein/REAXYS Number:
6119230

Key Documents

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Product Name

L-Histidine dihydrochloride, ≥99.0% (AT)

InChI key

XEJCDBUNISUVGZ-XRIGFGBMSA-N

InChI

1S/C6H9N3O2.2ClH/c7-5(6(10)11)1-4-2-8-3-9-4;;/h2-3,5H,1,7H2,(H,8,9)(H,10,11);2*1H/t5-;;/m0../s1

SMILES string

Cl.Cl.N[C@@H](Cc1c[nH]cn1)C(O)=O

assay

≥99.0% (AT)

form

powder or crystals

optical activity

[α]20/D +6.5±1°, c = 8% in H2O

ign. residue

≤0.1% (as SO4)

color

white

mp

240-245 °C (dec.)

solubility

H2O: soluble
saline: soluble

anion traces

sulfate (SO42-): ≤50 mg/kg

cation traces

As: ≤0.1 mg/kg
Cd: ≤5 mg/kg
Co: ≤5 mg/kg
Cu: ≤5 mg/kg
Fe: ≤5 mg/kg
NH4+: ≤500 mg/kg
Ni: ≤5 mg/kg
Pb: ≤5 mg/kg
Zn: ≤5 mg/kg

Quality Level

100

Related Categories

Biochem/physiol Actions

L-Histidine is a natural proteinogenic α amino acid useful as a cell growth supplement that support protein and peptide biosynthesis. L-Histidine is studied in a wide range of applications that involve imidazole chemistry and biochemisty.
L-Histidine is a positively charged imidazole-side chain containing α amino acid. It is metabolized to histamine and is a precursor of the dipeptide carnosine. As one of the 22 proteinogenic amino acids L-His is incorporated into proteins by translation processes in vitro. L-Histidine is an essential amino acid added to cell culture media.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCL4877
BCCJ7513
BCCJ5666
BCCC3647
BCBW3200

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Sadao Wakabayashi et al.
Seminars in thrombosis and hemostasis, 37(4), 389-394 (2011-08-02)
Histidine-rich glycoprotein (HRG) is one of the major plasma proteins and thought to function in blood coagulation, fibrinolysis, and innate immune systems. The amino acid sequence of HRG revealed a multidomain structure consisting of cystatin-like domains 1 and 2, a
Kirsten Jung et al.
Current opinion in microbiology, 15(2), 118-124 (2011-12-17)
Two-component systems, composed of a histidine kinase (HK) and a response regulator (RR), are the major signal transduction devices in bacteria. Originally it was thought that these two components function as linear, phosphorylation-driven stimulus-response system. Here, we will review how
Ana Reis et al.
Analytical and bioanalytical chemistry, 399(8), 2779-2794 (2011-02-01)
The radical oxidation of isomeric peptides containing one reactive amino acid [histidine (H)] and another less reactive amino acid [glycine (G)] in the form of dipeptides (HG and GH) and tripeptides (HGG, GHG, and GGH) was studied by mass spectrometry
Amir Abbas Farshid et al.
Indian journal of pharmacology, 45(2), 126-129 (2013-05-30)
Cyclophosphamide (CP), a widely used antineoplastic drug causes hemorrhagic cystitis (HC) mainly via induction of oxidative stress. Both vitamin C and histidine have antioxidant properties. The present study aimed to investigate the effects of oral (p.o.) administration of vitamin C
K Bjornsdottir-Butler et al.
International journal of food microbiology, 334, 108815-108815 (2020-09-24)
Histamine or scombrotoxin fish poisoning is caused by ingestion of bacterially produced histamine in fish. Histamine-producing bacteria generally contain the histidine decarboxylase gene (hdc). However, some strains of Photobacterium phosphoreum are known to produce significant levels of histamine, although the
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