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55845

1,2-Distearoyl-sn-glycero-3-phospho-rac-(1-glycerol) sodium salt

≥97.0% (TLC)

Synonym(s):

1,2-Dioctadecanoyl-sn-glycero-3-phospho-(1′-rac-glycerol) sodium salt, 1,2-Distearoyl-sn-glycero-3-phosphoglycerol, L-α-Phosphatidyl-DL-glycerol, distearoyl, DSPG-Na, Octadecanoic acid (1R)-1-[[[(2,3-dihydroxypropoxy)hydroxyphosphinyl]oxy]methyl]-1,2-ethanediyl ester monosodium salt, PG(18:0/18:0)

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About This Item

Empirical Formula (Hill Notation):
C42H82NaO10P
CAS Number:
200880-42-8
Molecular Weight:
801.06
NACRES:
NA.85
PubChem Substance ID:
329758166
UNSPSC Code:
51191904
MDL number:
MFCD00077290
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biological source

synthetic

assay

≥97.0% (TLC)

form

powder

functional group

ester

lipid type

phosphoglycerides

shipped in

dry ice

storage temp.

−20°C

SMILES string

[H][C@@](COP([O-])(OCC(O)CO)=O)(OC(CCCCCCCCCCCCCCCCC)=O)COC(CCCCCCCCCCCCCCCCC)=O.[Na+]

InChI

1S/C42H83O10P.Na/c1-3-5-7-9-11-13-15-17-19-21-23-25-27-29-31-33-41(45)49-37-40(38-51-53(47,48)50-36-39(44)35-43)52-42(46)34-32-30-28-26-24-22-20-18-16-14-12-10-8-6-4-2;/h39-40,43-44H,3-38H2,1-2H3,(H,47,48);/q;+1/p-1/t39?,40-;/m1./s1

InChI key

YNQYZBDRJZVSJE-QTOMIGAPSA-M

Biochem/physiol Actions

DSPG is the most efficient phosphatidylglycerol in enhancing respiratory mucus clearance in cystic fibrosis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCF1462
BCBS5155V
BCBJ9920V
1432669V
1432669

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R A Cunha et al.
FEBS letters, 469(2-3), 159-162 (2000-03-14)
Kainate receptors are ionotropic receptors, also reported to couple to G(i)/G(o) proteins, increasing neuronal excitability through disinhibition of neuronal circuits. We directly tested in hippocampal synaptosomes if kainate receptor-mediated inhibition of GABA release involved a metabotropic action. The kainate analogue
Reagan L Pennock et al.
Journal of neurophysiology, 115(5), 2376-2388 (2016-02-26)
Whereas the activation of Gαi/o-coupled receptors commonly results in postsynaptic responses that show acute desensitization, the presynaptic inhibition of transmitter release caused by many Gαi/o-coupled receptors is maintained during agonist exposure. However, an exception has been noted where GABAB receptor
Oksana Lenina et al.
Experimental physiology, 104(7), 1004-1010 (2019-05-11)
What is the central question of this study? Do GABA receptors play any role at the neuromuscular junction? What is the main finding and its importance? In the presence of either ionotropic or metabotropic GABA receptor antagonists, diaphragm muscle force
Matthias Braun et al.
The Journal of physiology, 559(Pt 2), 397-409 (2004-07-06)
We have investigated the regulation of hormone secretion from rat pancreatic islets by the GABAB receptors (GABABRs). Inclusion of the specific GABABR antagonist CGP 55845 in the extracellular medium increased glucose-stimulated insulin secretion 1.6-fold but did not affect the release
S Girod de Bentzmann et al.
The European respiratory journal, 6(8), 1156-1161 (1993-09-01)
We have previously shown that a decreased level of phosphatidylglycerol in cystic fibrosis (CF) respiratory mucus is partly responsible for its marked adhesiveness and stickiness, which impair mucus transport, and that distearoyl phosphatidylglycerol (DSPG) was the most efficient form of
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Global Trade Item Number

SKUGTIN
SML0594-5MG04061837100543
SML0594-25MG04061832076072
55845-1G04061826652909
55845-100MG04061833248959

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