57600
IL-2 human
≥98% (GE), recombinant, expressed in E. coli, liquid
Synonym(s):
Interleukin-2 human, TCGF, hIL-2, IL-2
Product Name
Interleukin-2 human, recombinant, expressed in E. coli, ~10000 U/mL
biological source
human
Quality Level
recombinant
expressed in E. coli
form
liquid
mol wt
Mr ~15500
packaging
vial of 1 mL
concentration
~10000 U/mL
color
colorless
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Gene Information
human ... IL2(3558)
Biochem/physiol Actions
Promotes the growth of IL-2 dependent lymphocytes. Amino acid sequence of IL-2.
Packaging
One vial contains 10′000 Units
Physical form
Clear; colorless solution in Dulbecco-PBS; containing 1 mg BSA/mL.
Other Notes
1 U corresponds to the unit activity in the colorimetric MTT-assay with CTLL-2 cells.
Sales restrictions may apply.
Disclaimer
Stable at −20 °C; prepare appropriate aliquots and avoid repeated freezing and thawing, since aggregation may occur resulting in apparent loss of activity.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Regulatory Information
低风险生物材料
常规特殊物品
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S Gillis et al.
Journal of immunology (Baltimore, Md. : 1950), 120(6), 2027-2032 (1978-06-01)
Several soluble factors have recently been associated with the proliferation and differentiation of thymus-derived lymphocytes. One of these factors present in medium conditioned by T cell mitogen-stimulated lymphocytes has the ability to promote the long-term culture of normal and antigen-specific
Interleukin 2.
K A Smith
Annual review of immunology, 2, 319-333 (1984-01-01)
R J Robb et al.
Proceedings of the National Academy of Sciences of the United States of America, 81(20), 6486-6490 (1984-10-01)
Human interleukin 2 was separated into multiple molecular forms by selective immunoaffinity chromatography and chromatofocusing. For the most part, this heterogeneity was attributed to variations in glycosylation of the threonine residue in position 3 of the polypeptide chain. The various
Denise L Cecil et al.
Cancer research, 74(10), 2710-2718 (2014-04-30)
Immunization against self-tumor antigens can induce T-regulatory cells, which inhibit proliferation of type I CD4(+) T-helper (TH1) and CD8(+) cytotoxic T cells. Type I T cells are required for potent antitumor immunity. We questioned whether immunosuppressive epitopes could be identified
Cecilie Brekke Rygh et al.
PloS one, 9(9), e108414-e108414 (2014-10-01)
There are currently no established radiological parameters that predict response to immunotherapy. We hypothesised that multiparametric, longitudinal magnetic resonance imaging (MRI) of physiological parameters and pharmacokinetic models might detect early biological responses to immunotherapy for glioblastoma targeting NG2/CSPG4 with mAb9.2.27
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