62320
(±)-α-Lipoic acid
≥98.0% (HPLC), solid
Synonym(s):
(±)-1,2-Dithiolane-3-pentanoic acid, 6,8-Dithiooctanoic acid, DL-α-Lipoic acid, DL-6,8-Thioctic acid, Lip(S2)
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CN¥178.03
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CN¥1,582.03
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CN¥4,543.02
250 G
CN¥14,521.69
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1 G
CN¥178.03
10 G
CN¥1,582.03
50 G
CN¥4,543.02
250 G
CN¥14,521.69
About This Item
Empirical Formula (Hill Notation):
C8H14O2S2
CAS Number:
Molecular Weight:
206.33
Beilstein:
81853
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.21
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Product Name
(±)-α-Lipoic acid, ≥98.0%
Quality Level
Assay
≥98.0% (HPLC)
≥98.0%
form
solid
ign. residue
≤0.1%
loss
≤0.2% loss on drying
bp
>286 °C/1.013 hPa
mp
60-62 °C
solubility
water: 0.87 g/L at 22 °C
density
1.4 g/cm3 at 23 °C
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Related Categories
1 of 4
This Item | I8000 | I141 | P26600 |
|---|---|---|---|
| reaction suitability reagent type: oxidant | reaction suitability - | reaction suitability - | reaction suitability - |
| Quality Level 100 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form solid | form powder | form emulsion | form powder |
| contains stabilizer | contains - | contains - | contains - |
| concentration 45 wt. % (IBX) | concentration - | concentration 20% | concentration - |
General description
α-lipoic acid (ALA, thioctic acid) is a natural organosulfur compound produced in plants, animals and humans. It is a powerful antioxidant and plays a role in the forming nucleic acids, building blocks of DNA.[1]
This product is a racemic mixture.
This product is a racemic mixture.
Application
Biochem/physiol Actions
(±)-α-Lipoic acid exhibits direct free radical scavenging property[4] and reduces the increased oxidative stress.[5] In addition, it might also exhibit prooxidant activity.[4] α-Lipoic acid functions as an important prosthetic group in α-keto acid dehydrogenase complexes of the mitochondria.[6] It acts as a potential therapeutic for diabetic patients with distal symmetric polyneuropathy (DSP).[5] α-Lipoic acid is also used in the treatment of energy-impaired and redox unbalanced diseases.[6]
Antioxidant and coenzyme needed for the activity of enzyme complexes such as pyruvate dehydrogenase and glycine decarboxylase.
Antioxidant and coenzyme needed for the activity of enzyme complexes such as those of pyruvate dehydrogenase and glycine decarboxylase. Exogenous thioctic acid is reduced intracellularly by two or more enzymes. The reduced form then influences a number of cell processes by direct radical scavenging, recycling of other antioxidants, increasing glutathione synthesis, and modulating transcription factor activity particularly that of NF-κB. Decreases the phagocytosis of myelin by macrophages.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Irrit. 2 - Skin Irrit. 2 - Skin Sens. 1
Storage Class Code
11 - Combustible Solids
WGK
WGK 2
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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