67376
Sodium (R)-homocitrate tribasic
≥90.0%
Synonym(s):
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid trisodium salt, (R)-Homocitrate trisodium salt
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About This Item
Empirical Formula (Hill Notation):
C7H7Na3O7
CAS Number:
Molecular Weight:
272.10
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352200
MDL number:
InChI key
SNTBDRNHMPWDFS-LSBIWMFESA-K
SMILES string
[Na+].[Na+].[Na+].O[C@](CCC([O-])=O)(CC([O-])=O)C([O-])=O
InChI
1S/C7H10O7.3Na/c8-4(9)1-2-7(14,6(12)13)3-5(10)11;;;/h14H,1-3H2,(H,8,9)(H,10,11)(H,12,13);;;/q;3*+1/p-3/t7-;;;/m1.../s1
assay
≥90.0%
optical activity
[α]/D -11.0±2.0°, c = 0.1 in H2O
impurities
≤15.0% water
Application
(R)-Homocitrate trisodium salt may be used in studies of formation and function of the iron-molybdenum cofactor (FeMo-co) which contains 7Fe, 9S, Mo, R-homocitrate. FeMo-co is essential for nitrogen fixation by nitrogenous organisms.
Biochem/physiol Actions
Important metabolite of lysine biosynthesis, pyruvate and 2-oxocarboxylic acid metabolism, homocitrate is as a sensor of lysine-pathway distress, it has a dynamic role during nitrogen fixation.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
signalword
Warning
hcodes
pcodes
Hazard Classifications
Eye Irrit. 2
Storage Class
13 - Non Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
Regulatory Information
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Yilin Hu et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(46), 17125-17130 (2006-10-26)
The Fe protein is indispensable for nitrogenase catalysis and biosynthesis. However, its function in iron-molybdenum cofactor (FeMoco) biosynthesis has not been clearly defined. Here we show that the Fe protein can act as a Mo/homocitrate insertase that mobilizes Mo/homocitrate for
Marcus C Durrant et al.
The Biochemical journal, 397(2), 261-270 (2006-03-29)
Although it is generally accepted that the active site of nitrogenase is located on the FeMo-cofactor, the exact site(s) of N2 binding and reduction remain the subject of continuing debate, with both molybdenum and iron atoms being suggested as key
L Ma et al.
The Journal of biological chemistry, 269(27), 18007-18015 (1994-07-08)
Here we report the large scale isolation and characterization of a species, designated MoFe cluster, that exhibits an S = 3/2 EPR signal, and the comparison of this entity to isolated FeMo cofactor in N-methylformamide and to the active site
Franco Teves et al.
Microbiology (Reading, England), 155(Pt 12), 3881-3892 (2009-08-22)
The lysine biosynthetic pathway has to supply large amounts of alpha-aminoadipic acid for penicillin biosynthesis in Penicillium chrysogenum. In this study, we have characterized the P. chrysogenum L2 mutant, a lysine auxotroph that shows highly increased expression of several lysine
J Imperial et al.
Biochemistry, 28(19), 7796-7799 (1989-09-19)
(R)-2-Hydroxy-1,2,4-butanetricarboxylic acid [(R)-homocitrate] has been has been recently reported to be an integral constituent of the otherwise thought to be inorganic iron-molybdenum cofactor of dinitrogenase [Hoover, T.R., Imperial, J., Ludden, P.W., & Shah, V.K. (1989) Biochemistry 28,2768-2771]. Different organic acids
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