70215
2,3-Naphthalenedicarboxaldehyde
suitable for fluorescence
Synonym(s):
NDA
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About This Item
Linear Formula:
C10H6(CHO)2
CAS Number:
Molecular Weight:
184.19
UNSPSC Code:
12352108
NACRES:
NA.32
PubChem Substance ID:
MDL number:
Beilstein/REAXYS Number:
2207267
Form:
crystals
form
crystals
Quality Level
impurities
≤2% mono- and dicarboxylic acid (1H-NMR)
mp
131-133 °C (lit.), 132-135 °C
fluorescence
λex 420 nm; λem ~480 nm in 0.1 M borate pH 9.3 (after derivatization with glycine [~90 μM glycine, ~20 μM N-])
suitability
suitable for fluorescence
storage temp.
2-8°C
SMILES string
[H]C(=O)c1cc2ccccc2cc1C([H])=O
InChI
1S/C12H8O2/c13-7-11-5-9-3-1-2-4-10(9)6-12(11)8-14/h1-8H
InChI key
ZIPLKLQPLOWLTM-UHFFFAOYSA-N
General description
2,3-Naphthalenedicarboxaldehyde, also known as NDA, is a novel fluorescent derivatization agent. The fluorescence max. excitation of NDA is in the range of 424 nm and max. emission is achieved at 484nm.
2,3-Naphthalenedicarboxaldehyde is a fluorescent derivatization agent of primary amines, amino acids, and small peptides. The reaction between the amino compounds and NDA results in highly fluorescent and stable derivative compounds.
2,3-Naphthalenedicarboxaldehyde is a fluorescent derivatization agent of primary amines, amino acids, and small peptides. The reaction between the amino compounds and NDA results in highly fluorescent and stable derivative compounds.
Application
2,3-Naphthalenedicarboxaldehyde is used as a fluorescent labelling agent for quantification of Histamine in human immunoglobulin preparations. NAD is used as a derivatization agent for glutathione to quantify protein glutathionylation. It is a suitable reagent used for the development of fluorescence-based microtiter plate assay for γ-glutamylcyclotransferase.
Features and Benefits
NDA based fluorescent assays have the following benefits over O-Phthalaldehyde (OPA):
- High Reaction rate.
- High Fluorescence quantum yield.
- No uncommon excitation wavelength.
- No side reactions.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Global Trade Item Number
| SKU | GTIN |
|---|---|
| 70215-500MG | 04061833278116 |
| 70215-100MG | 04061832820705 |