74148
D-myo-Inositol 1,4,5-triphosphate tripotassium salt
≥80% (HPLC)
Synonym(s):
Ins(1,4,5)P3
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About This Item
Empirical Formula (Hill Notation):
C6H12K3O15P3
CAS Number:
Molecular Weight:
534.37
NACRES:
NA.32
PubChem Substance ID:
UNSPSC Code:
12352108
MDL number:
Assay:
≥80% (HPLC)
Form:
solid
InChI
1S/C6H15O15P3.3K/c7-1-2(8)5(20-23(13,14)15)6(21-24(16,17)18)3(9)4(1)19-22(10,11)12;;;/h1-9H,(H2,10,11,12)(H2,13,14,15)(H2,16,17,18);;;/q;3*+1/p-3/t1-,2+,3+,4-,5-,6-;;;/m1.../s1
SMILES string
O[C@@H]1[C@@H](OP(O)([O-])=O)[C@H](OP(O)([O-])=O)[C@@H](O)[C@@H](O)[C@H]1OP(O)([O-])=O.[K+].[K+].[K+]
InChI key
MQMSEISCCNPXIL-ZKVWPJASSA-K
assay
≥80% (HPLC)
form
solid
storage temp.
−20°C
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
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I-Shan Chen et al.
Journal of biomedical science, 18, 2-2 (2011-01-08)
This study investigates whether protein kinase G (PKG), protein kinase A (PKA) and protein kinase C (PKC) are involved in the regulatory mechanisms of store-operated channel (SOC) in pulmonary arteries. Pulmonary artery smooth muscle cells (PASMCs) were enzymatically dissociated from
Francis Wolfram et al.
The Biochemical journal, 428(3), 483-489 (2010-04-10)
IP3Rs (inositol 1,4,5-trisphosphate receptors) are the intracellular channels that mediate release of Ca2+ from the endoplasmic reticulum in response to the many stimuli that evoke Ins(1,4,5)P3 formation. We characterized and purified type 1 IP3R heterologously expressed in Sf9 insect cells
Robert Duliński et al.
Biomolecules, 10(2) (2020-01-25)
A relatively high concentration of phytate in buckwheat malt, and the low activity of endogenous buckwheat phytases, both of which limit the effective use of substrates (starch, proteins, minerals) for fermentation and yeast metabolism, gives rise to the potential for
M Hirata et al.
The Journal of biological chemistry, 264(34), 20303-20308 (1989-12-05)
A series of inositol 1,4,5-trisphosphate (IP3) analogs and positional isomers was examined to explore the structure-activity relationships among IP3 5-phosphatase, IP3 3-kinase, and the release of Ca2+. All analogs with additional groups on the 2nd position of IP3 inhibited the
Igor Cestari et al.
Molecular biology of the cell, 29(9), 1137-1152 (2018-03-09)
Many cellular processes change during the Trypanosoma brucei life cycle as this parasite alternates between the mammalian host and tsetse fly vector. We show that the inositol phosphate pathway helps regulate these developmental changes. Knockdown of inositol polyphosphate multikinase (IPMK)
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