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Merck
CN

74385

Nonidet P 40 Substitute

BioXtra, mixture of 15 homologues

Synonym(s):

4-Nonylphenyl-polyethylene glycol, Imbentin-N/52, NP 40

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About This Item

CAS Number:
NACRES:
NA.25
UNSPSC Code:
12161900
MDL number:
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description

TLC: corresponds to standard, non-ionic

product line

BioXtra

form

liquid

mol wt

average mol wt 680

refractive index

n20/D 1.49

pH

5-8 (5% in H2O)

CMC

0.059 mM (20-25°C)

transition temp

cloud point 45-50 °C

density

1.06 g/mL at 20 °C

anion traces

chloride (Cl-): ≤500 mg/kg, sulfate (SO42-): ≤100 mg/kg

cation traces

Ca: ≤10 mg/kg, Cd: ≤5 mg/kg, Co: ≤5 mg/kg, Cr: ≤5 mg/kg, Cu: ≤5 mg/kg, Fe: ≤5 mg/kg, K: ≤1000 mg/kg, Li: ≤5 mg/kg, Mg: ≤5 mg/kg, Mn: ≤5 mg/kg, Mo: ≤5 mg/kg, Na: ≤50 mg/kg, Ni: ≤5 mg/kg, Pb: ≤5 mg/kg, Zn: ≤5 mg/kg

HLB

13.5

InChI

1S/C19H32O3/c1-2-3-4-5-6-7-8-9-18-10-12-19(13-11-18)22-17-16-21-15-14-20/h10-13,20H,2-9,14-17H2,1H3

InChI key

BLXVTZPGEOGTGG-UHFFFAOYSA-N

Application

Non-ionic surfactant, used to solubilize cerebral GABA receptors. Used in solubilization of proteins and lipids of the scallop gill ciliary membrane and of membranes from breast cancer tumors.

Legal Information

Nonidet is a trademark of Shell Chemical Co.

Disclaimer

May become turbid on storage; a clear product can be obtained on heating to 40°C.

pictograms

Exclamation markEnvironment

Storage Class

10 - Combustible liquids

ppe

Eyeshields, Gloves, type ABEK (EN14387) respirator filter

flash_point_f

212.0 °F - closed cup

flash_point_c

100 °C - closed cup

signalword

Danger

Hazard Classifications

Aquatic Acute 1 - Aquatic Chronic 1 - ED ENV 1 - Eye Irrit. 2 - Skin Irrit. 2

Regulatory Information

危险化学品

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Ito, Y.
Int. Congr. Ser. - Excerpta Med., 565, 31633-31633 (1982)
B Schraag et al.
Analytical biochemistry, 211(2), 233-239 (1993-06-01)
A procedure for an enzyme-linked immunosorbent assay for the determination of protein tyrosine kinase (PTK) activity from cytosolic and solubilized membrane fractions from breast cancers, is described. The general PTK substrate poly(GluNa, Tyr) 4:1 is coated to the wells of
R E Stephens
The Journal of cell biology, 100(4), 1082-1090 (1985-04-01)
The proteins and lipids of the scallop gill ciliary membrane may be reassociated through several cycles of detergent solubilization, detergent removal, and freeze-thaw, without significant change in overall protein composition. Membrane proteins and lipids reassociate to form vesicles of uniform
Laura Jacobs et al.
Oncotarget, 8(45), 78917-78929 (2017-11-08)
Aberrant B-cell receptor (BCR) signaling is known to contribute to malignant transformation. Two small molecule inhibitors targeting BCR pathway signaling include ibrutinib, a Bruton's tyrosine kinase (BTK) inhibitor, and idelalisib, a specific Phosphatidylinositol-4,5-bisphosphate 3-kinase delta (PI3Kδ) inhibitor, both of which
Elise Malek-Adamian et al.
Nucleic acid therapeutics, 29(4), 187-194 (2019-05-16)
In this study, we explore the effect of a library of 2'-, 4'-, and 2',4'-modified uridine nucleosides and their impact on silencing firefly luciferase and on down-regulated in renal cell carcinoma (DRR) gene targets. The modifications studied were 2'-F-ribose, 2'-F-arabinose

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