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Merck
CN

80198

Methoxatin disodium salt

≥97.0% (HPLC)

Synonym(s):

PQQ, Pyrrolo-quinoline-quinone disodium salt

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About This Item

Empirical Formula (Hill Notation):
C14H4N2Na2O8
CAS Number:
122628-50-6
Molecular Weight:
374.17
NACRES:
NA.79
PubChem Substance ID:
329768729
UNSPSC Code:
12352005
MDL number:
MFCD00151711

Key Documents

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Product Name

Methoxatin disodium salt, ≥97.0% (HPLC)

InChI key

UFVBOGYDCJNLPM-UHFFFAOYSA-L

SMILES string

OC(=O)c1cc(nc2C(=O)C(=O)c3cc([nH]c3-c12)C(=O)O[Na])C(=O)O[Na]

InChI

1S/C14H6N2O8.2Na/c17-10-4-2-6(14(23)24)15-8(4)7-3(12(19)20)1-5(13(21)22)16-9(7)11(10)18;;/h1-2,15H,(H,19,20)(H,21,22)(H,23,24);;/q;2*+1/p-2

biological source

fermentation/recombinant

assay

≥97.0% (HPLC)

form

powder

color

red-brown to deep orange
 red-brown to deep red-brown

storage temp.

2-8°C

Quality Level

100

Related Categories

Application


  • Safety assessment of a novel, dietary pyrroloquinoline quinone disodium salt (mnemoPQQ): This study investigates the safety profile of Methoxatin disodium salt, which has implications for its application in assay development for clinical and diagnostic purposes. Specifically, it addresses the compound′s use in dietary supplements and potential crossover into clinical assays where safety and toxicity are paramount (Shiojima et al., 2022).


Biochem/physiol Actions

In bacteria, pyrroloquinoline quinone (PQQ) is used as a redox cycling cofactor. It acts as a cofactor (prosthetic group) for enzyme-catalyzed redox reactions of glucose and methanol dehydrogenase(s). PQQ is used in liposomes to establish a simple homogeneous assay for the detection of membrane permeabilization by antimicrobial peptides and synthetic copolymers. In bovine plasma amine oxidase, methoxatin may acts as the cofactor.

General description

Methoxatin/pyrroloquinoline quinone (PQQ) is mostly seen in plants, few bacteria and single cell eukaryotes, like yeast. It is mainly obtained from methylotrophic bacteria. PQQ may also present in the tissues of mammals.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN2365
BCCJ8330
BCCD8905
BCCB1989
BCBR8576V

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  1. Which document(s) contains shelf-life or expiration date information for a given product?

    If available for a given product, the recommended re-test date or the expiration date can be found on the Certificate of Analysis.

  2. How do I get lot-specific information or a Certificate of Analysis?

    The lot specific COA document can be found by entering the lot number above under the "Documents" section.

  3. How do I find price and availability?

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  4. What is the Department of Transportation shipping information for this product?

    Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product. 

  5. What solvents can be used to reconstitute Product 80198, Methoxatin?

    Product 80198, Methoxatin disodium salt is soluble in water up to 3 mg/ml. The following reference by Zimmerman, L.B. et al., Analytical Biochemistry, 411 (2), 194-199 (2011) has solubilized the product in 250 μM in HEPES buffer (20 mM, pH 7.0, 290 mOsmol/kg).

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Oxidative stress is known to be associated with various age-related diseases. D-galactose (D-gal) has been considered a senescent model which induces oxidative stress response resulting in memory dysfunction. Pyrroloquinoline quinone (PQQ) is a redox cofactor which is found in various
Evidence for methoxatin (pyrroloquinolinequinone) as the cofactor in bovine plasma amine oxidase from resonance Raman spectroscopy
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Proceedings of the National Academy of Sciences of the USA, 83(22), 8435-8439 (1986)
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