82415
Prunetin
≥98.0% (TLC)
Synonym(s):
4′,5-Dihydroxy-7-methoxyisoflavone
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About This Item
Empirical Formula (Hill Notation):
C16H12O5
CAS Number:
Molecular Weight:
284.26
UNSPSC Code:
51111800
NACRES:
NA.77
PubChem Substance ID:
EC Number:
209-018-5
Beilstein/REAXYS Number:
292155
MDL number:
Product Name
Prunetin, ≥98.0% (TLC)
InChI key
KQMVAGISDHMXJJ-UHFFFAOYSA-N
InChI
1S/C16H12O5/c1-20-11-6-13(18)15-14(7-11)21-8-12(16(15)19)9-2-4-10(17)5-3-9/h2-8,17-18H,1H3
SMILES string
COc1cc(O)c2C(=O)C(=COc2c1)c3ccc(O)cc3
assay
≥98.0% (TLC)
form
powder
Quality Level
Biochem/physiol Actions
Inhibitor of both cytoplasmic and mitochondrial human liver aldehyde dehydrogenases, possibly by binding at an allosteric site.
Packaging
Bottomless glass bottle. Contents are inside inserted fused cone.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Ruth N Muchiri et al.
Journal of AOAC International, 103(4), 1160-1166 (2020-11-27)
Extracts of red clover (Trifolium pratense L.) containing estrogenic and pro-estrogenic isoflavones are used in dietary supplements primarily for the management of menopausal symptoms in women. A UHPLC-MS/MS assay was developed and validated for the quantitative analysis of the six
N S Nagarajan et al.
Natural product research, 20(2), 195-200 (2005-12-02)
Two isoflavonoids isolated from Dalbergia sympathetica were identified as 5,4'-dihydroxy-7-methoxyisoflavone (1) (Prunetin) and Prunetin-4'-O-beta-D-gentiobioside (2) (Dalsympathetin). The natural occurrence of Dalsympathetin is reported for the first time. The position of glycosylation in Dalsympathetin at 4'-position has been confirmed by 2D-NMR
Stephen W J Wang et al.
The Journal of pharmacology and experimental therapeutics, 329(3), 1023-1031 (2009-03-07)
Flavonoids have poor bioavailabilities largely because of metabolism via UDP-glucuronosyltransferases (UGTs). This study aims to further understand the functions of UGT in metabolizing genistein and apigenin, two compounds metabolized more extensively in the gut than in the liver. Because Gunn
Hyun Jae Lee et al.
Phytotherapy research : PTR, 25(8), 1196-1200 (2011-02-10)
This study investigated whether prunetin significantly affects the secretion, production and gene expression of mucin from cultured airway epithelial cells. Confluent primary rat tracheal surface epithelial (RTSE) cells were pretreated with adenosine triphosphate (ATP) for 5 min and then chased for
Nattaya Ngamrojanavanich et al.
Journal of ethnopharmacology, 109(2), 354-358 (2006-09-16)
A carpin (3-hydroxy-9-methoxypterocarpan) (Medicarpin) (1) and four isoflavones, 7-hydroxy-4'-methoxy-isoflavone (Formononetin) (2); 7,4'-dimethoxyisoflavone (3); 5,4'-dihydroxy-7-methoxy-isoflavone (Prunetin) (4) and 7-hydroxy-6,4'-dimethoxyisoflavone (5) were isolated from the tuber roots of Butea superba Roxb. Compounds 2 and 4 showed moderate cytotoxic activity on KB cell
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