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Merck
CN

83695

Rhodamine 110 chloride

suitable for fluorescence, BioReagent, ≥99.0% (UV)

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About This Item

Empirical Formula (Hill Notation):
C20H14N2O3 · HCl
CAS Number:
13558-31-1
Molecular Weight:
366.80
UNSPSC Code:
12171500
NACRES:
NA.32
PubChem Substance ID:
57652964
EC Number:
236-944-7
Beilstein/REAXYS Number:
4631860
MDL number:
MFCD00042009

Key Documents

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Product Name

Rhodamine 110 chloride, suitable for fluorescence, BioReagent, ≥99.0% (UV)

InChI key

JNGRENQDBKMCCR-UHFFFAOYSA-N

InChI

1S/C20H14N2O3.ClH/c21-11-5-7-15-17(9-11)25-18-10-12(22)6-8-16(18)19(15)13-3-1-2-4-14(13)20(23)24;/h1-10,21H,22H2,(H,23,24);1H

SMILES string

Cl.Nc1ccc2c(OC3=CC(=N)C=CC3=C2c4ccccc4C(O)=O)c1

product line

BioReagent

assay

≥99.0% (UV)

form

crystals

mp

>300 °C (lit.)

solubility

ethanol: soluble
methanol: soluble

fluorescence

λex 498 nm; λem 520 nm in methanol

suitability

suitable for fluorescence

Quality Level

200

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Application

Rhodamine 110 is used for the determination of protease activity with accurate kinetic parameters. It is used to measure caspase activity in cells with induced apoptosis.

General description

Rhodamine 110 or R110 is a triphenylmethane dye and emits a strong green-fluorescent light. The high fluorescence is attributed to the presence of amino groups as electron donating groups. Rhodamine 110 has excitation and emission maximum at 502.4/521.6 nm, respectively.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
BCCN1532
BCCJ8101
BCCK3189
BCCH6230
BCCG1785

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H Hug et al.
Biochemistry, 38(42), 13906-13911 (1999-10-21)
Caspases (cysteine aspartate-specific proteases) are a structurally related group of cysteine proteases that cleave peptide bonds following specific recognition sequences. They play a central role in activating apoptosis of vertebrate cells. To measure apoptosis induced by various stimuli and at
Sambashiva Banala et al.
ACS chemical biology, 7(2), 289-293 (2011-10-27)
A caged rhodamine 110 derivative for the specific labeling of SNAP-tag fusion proteins is introduced. The caged rhodamine 110 derivative permits the labeling of cell surface proteins in living cells and of intracellular proteins in fixed cells. The probe requires
Saijie Zhu et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 37(5), 573-580 (2009-05-16)
The present study was aimed to investigate the effects of polyoxyethylene (40) stearate (PS), a non-ionic surfactant, on the activity of P-glycoprotein (P-gp) and six major cytochrome P450 (CYP) isoforms. An in vitro diffusion chamber system was utilized to estimate
Marcos M Pires et al.
Organic letters, 10(5), 837-840 (2008-02-09)
Glutathione is a crucial component of the redox homeostasis of cells, and altered levels have been linked to human pathologies. We constructed a latent fluorophore (RhoSS) that responds to cellular thiols in vitro and in cyto following intracellular reduction by
Melissa M Yatzeck et al.
Bioorganic & medicinal chemistry letters, 18(22), 5864-5866 (2008-07-04)
A derivative of rhodamine 110 has been designed and assessed as a probe for cytochrome P450 activity. This probe is the first to utilize a 'trimethyl lock' that is triggered by cleavage of an ether bond. In vitro, fluorescence was
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