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905H-0

Cytokeratin 5 (EP1601Y) + Cytokeratin 14 (LL002)

Name: Cytokeratin 5 (EP1601Y) + Cytokeratin 14 (LL002)
Brand: SIGMA

Mouse and Rabbit Monoclonal Antibody

Synonym(s):

Cytokeratin 5 (EP1601Y) + Cytokeratin 14 (LL002) Mouse and Rabbit Monoclonal Antibody

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About This Item

NACRES:

NA.41

UNSPSC Code:

12352203

Conjugate:

unconjugated

Clone:

EP1601Y + LL002, monoclonal

Application:

—

Citations:

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Properties

Quality Segment

100, 500

biological source

mouse, rabbit

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

EP1601Y + LL002, monoclonal

description

For In Vitro Diagnostic Use in Select Regions (See Chart)

form

buffered aqueous solution

species reactivity

human

packaging

bottle of 1.0 mL predilute (905H-07), bottle of 7.0 mL predilute (905H-08)

manufacturer/tradename

Cell Marque^®

concentration

0.1-1.5 μg/mL (predilute)

isotype

IgG3, IgG

shipped in

wet ice

storage temp.

2-8°C

Gene Information

human ... KRT5(3852)

Description

General description

Cytokeratin 5 is an intermediate filament protein of 58 kD molecular wt. amongst the cytokeratin family. It is a type II (basic) cytokeratin. Antibodies to this protein identify basal cells of squamous and glandular epithelia, myoepithelia, and mesothelium. Cytokeratin 14 is a 50 kD polypeptide found in basal cells of squamous epithelia, some glandular epithelia, myoepithelium, and mesothelial cells. Anti-Cytokeratin 5 has been useful in the differential diagnosis of metastatic carcinoma in the pleura versus epithelial mesothelioma. Almost all squamous cell carcinomas, half of transitional carcinomas, and many undifferentiated large cell carcinomas immunostain with CK5. Anti-CK14 has been demonstrated to be useful in differentiating squamous cell carcinomas from other epithelial tumors. Anti-CK5, along with anti-CK14, has found application in identifying the basaloid phenotype of breast carcinoma, a tumor with poor prognosis.

Physical form

Solution in Tris Buffer, pH 7.3-7.7, with 1% BSA and <0.1% Sodium Azide

Preparation Note

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