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Merck
CN

A4056

Amrinone

Synonym(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

Empirical Formula (Hill Notation):
C10H9N3O
CAS Number:
60719-84-8
Molecular Weight:
187.20
UNSPSC Code:
12352202
PubChem Substance ID:
24890741
EC Number:
262-390-0
MDL number:
MFCD00083228

Key Documents

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assay

≥98% (TLC)

Quality Level

200

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

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Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN8464V
MKBR5516V
SLBG7032V
037K1457
037K1458

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Thiranat Tanwiphongtrakun et al.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists, 44(3), 183-185 (2006-10-14)
We came across a case who because of sustained hypotension with normal cardiac output was given amrinone which offered an initial excellent response but showed impotency later and its replacement by milrinone dramatically improved the hemodynamic status. The ensuing hypotension
Kiyokazu Yunomae et al.
Journal of applied toxicology : JAT, 27(1), 78-85 (2006-12-06)
It is presumed that phosphodiesterase (PDE) inhibitors have two mechanisms for inhibition of hERG currents in the acute applications to cells: direct channel block, and downregulation of human ether-a-go-go related gene (hERG) activities by PKA-dependent pathway mediated phosphorylation through their
Nuria Albet-Torres et al.
The Journal of biological chemistry, 284(34), 22926-22937 (2009-06-13)
Amrinone is a bipyridine compound with characteristic effects on the force-velocity relationship of fast skeletal muscle, including a reduction in the maximum shortening velocity and increased maximum isometric force. Here we performed experiments to elucidate the molecular mechanisms for these
Greene Shepherd
American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 63(19), 1828-1835 (2006-09-23)
The toxic effects and treatment of beta-adrenergic blocker and calcium-channel blocker (CCB) overdose are reviewed. Overdoses with cardiovascular drugs are associated with significant morbidity and mortality. Beta-blockers and CCBs represent the most important classes of cardiovascular drugs. In overdose, beta-blockers
Alousi, A.A., et al.
Federation Proceedings, 37, 3692-3692 (1978)
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