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Merck
CN

A4056

Amrinone

Synonym(s):

5-Amino-(3,4′-bipyridin)-6(1H)-one, Inamrinone

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About This Item

Empirical Formula (Hill Notation):
C10H9N3O
CAS Number:
60719-84-8
Molecular Weight:
187.20
UNSPSC Code:
12352202
PubChem Substance ID:
24890741
EC Number:
262-390-0
MDL number:
MFCD00083228

Key Documents

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InChI key

RNLQIBCLLYYYFJ-UHFFFAOYSA-N

InChI

1S/C10H9N3O/c11-9-5-8(6-13-10(9)14)7-1-3-12-4-2-7/h1-6H,11H2,(H,13,14)

SMILES string

NC1=CC(=CNC1=O)c2ccncc2

assay

≥98% (TLC)

form

powder

solubility

1 M NaOH: 100 mg/mL

storage temp.

2-8°C

Quality Level

200

Gene Information

human ... PDE3A(5139)
rat ... Pde3a(50678)

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Biochem/physiol Actions

Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action.
Simple, non-glycoside cardiotonic agent, possibly via its phosphodiesterase III (PDE-III) inhibitory action. Independent of its cardiac effects, amrinone provides protection against ischemia-reperfusion injury in kidney, liver, and heart.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
SLBN8464V
MKBR5516V
SLBG7032V
037K1457
037K1458

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M P Rechtman et al.
European journal of pharmacology, 402(3), 255-262 (2000-08-26)
We investigated the effects of amrinone on ischaemia-induced changes in myocardial function in isolated rat hearts. Isolated hearts from male Sprague-Dawley rats (150-275 g) were perfused with physiological salt solution at a constant flow rate. The effects of amrinone (30
Kazuo Komamura et al.
Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research, 11 Suppl 1, S39-S42 (2008-04-17)
Phosphodiesterase (PDE) III inhibitor therapy is effective for treatment of acute decompensated heart failure (ADHF). Nevertheless, this drug is expensive than conventional inotropic agent dobutamine. We compared total medication costs of the patients treated with PDE III inhibitor amrinone therapy
Seyed Mohammad-Taghi Mansouri et al.
Iranian biomedical journal, 12(2), 77-84 (2008-05-29)
Selective phosphodiesterase (PDE3) inhibitors improve cardiac contractility and may use in congestive heart failure. However, their proarrhythmic potential is the most important side effect. In this research, we evaluated the potential cardiotonic activity of six new synthesized selective PDE3 inhibitors
R Karabulut et al.
Urological research, 30(3), 164-168 (2002-07-12)
Renal ischemia/reperfusion injury could arise as a consequence of clinical conditions such as renal transplantation, shock, cardiac arrest, hemorrhage and renal artery surgery. In this experimental study, we aimed to determine the preventive effects of amrinone on bilateral renal ischemia/reperfusion
Yoshihiro Ko et al.
Annals of thoracic and cardiovascular surgery : official journal of the Association of Thoracic and Cardiovascular Surgeons of Asia, 15(5), 311-317 (2009-11-11)
Phosphodiesterase (PDE) III inhibitors have been reported in various cellular protective activities via the cyclic adenosine monophosphate (cAMP) pathway. We investigated the effects of amrinone on ischemia/reperfusion injury and intracellular calcium (Ca2+) handling if utilized as a component of terminal
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