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A5285

Adenosine 5′-diphosphate monopotassium salt dihydrate

Name: Adenosine 5&#8242;-diphosphate monopotassium salt dihydrate
Brand: SIGMA

bacterial, ≥95%, P2Y receptor agonist, powder

Synonym(s):

Adenosine 5′-Diphosphate Potassium Salt, ADP

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About This Item

Empirical Formula (Hill Notation):

C₁₀H₁₄KN₅O₁₀P₂ · 2H₂O

CAS Number:

72696-48-1

Molecular Weight:

501.32

UNSPSC Code:

41106305

eCl@ss:

32160414

PubChem Substance ID:

24890964

NACRES:

NA.77

MDL number:

MFCD00066472

Assay:

≥95%

Form:

powder

Quality level:

200

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Product Name

Adenosine 5′-diphosphate monopotassium salt dihydrate, bacterial, ≥95%, powder

biological source

bacterial

Quality Level

200

assay

≥95%

form

powder

storage temp.

−20°C

SMILES string

[O-]P(OP(OC[C@H]([C@@H](O)[C@H]1O)O[C@H]1N2C3=C(N=C2)C(N)=NC=N3)(O)=O)(O)=O.[K+]

InChI

1S/C10H15N5O10P2.K/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20;/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20);/q;+1/p-1/t4-,6-,7-,10-;/m1./s1

InChI key

ZNCWUOPIJTUALR-MCDZGGTQSA-M

Gene Information

human ... HSP90AA1(3320), P2RY1(5028)

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Related Categories

Bioactive Small Molecules

Phosphates

Bioactive Small Molecule Agonists

General description

Adenosine diphosphate (ADP) is a crucial component for energy flow in living organisms. Its structure consists of a sugar backbone connected to adenine and two phosphate groups attached to the fifth carbon atom of the ribose sugar. ADP serves a precursor for ATP biosynthesis. ADP acts as a weak platelet agonist, specifically targeting the P2Y receptor. However, ADP plays a vital role in platelet function by enhancing the effects of other platelet agonists and promoting the stability of platelet aggregates when released from platelet dense granules.

Application

Adenosine 5′-diphosphate monopotassium salt dihydrate (ADP) has been used:

in titration to determine complex I-supported respiration in permeabilized muscle fibers
in titrations to determine ADP-stimulated respiratory kinetics
in the preparation of ADP solution for measuring mitochondrial respiration

Adenosine 5′-diphosphate has been used to study the release, neuronal effects, and removal of extracellular β-nicotinamide adenine dinucleotide (β-NAD⁺) in the rat brain. Adenosine 5′-diphosphate has also been used to compare prasugrel versus clopidogrel antiplatelet therapy after acute coronary syndrome.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Correlation between Labeling Yield and Surface Accessibility in Covalent Labeling Mass Spectrometry.

Daniel S Ziemianowicz et al.

Journal of the American Society for Mass Spectrometry, 31(2), 207-216 (2020-02-08)

The functional properties of a protein are strongly influenced by its topography, or the solvent-facing contour map of its surface. Together with crosslinking, covalent labeling mass spectrometry (CL-MS) has the potential to contribute topographical data through the measurement of surface

Roles of AMP, ADP, ATP, and AMPK in Healthy Energy Boosting and Prolonged Life Span

Yadav D , et al.

Chemistry & Biology (2017)

The Platelet P2 Receptors

Cattaneo M

Platelets (2013)

Metabolic remodeling of dystrophic skeletal muscle reveals biological roles for dystrophin and utrophin in adaptation and plasticity

Hardee JP, et al.

Molecular Metabolism (2021)

Protocol for Measurement of Oxygen Consumption Rate In Situ in Permeabilized Cardiomyocytes

Gao M, et al.

STAR protocols (2020)

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Global Trade Item Number

SKU	GTIN
A5285-5X1G	04061833375716
A5285-1G	04061835258154
A5285-100MG	04061832088662

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