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B2006

2,4′-Dibromoacetophenone

Name: 2,4′-Dibromoacetophenone
Brand: SIGMA

≥98% (HPLC), powder

Synonym(s):

4′-Bromophenacyl bromide

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About This Item

Linear Formula:

BrC₆H₄COCH₂Br

CAS Number:

99-73-0

Molecular Weight:

277.94

EC Number:

202-783-6

UNSPSC Code:

12352103

MDL number:

MFCD00000200

Beilstein/REAXYS Number:

607604

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Properties

assay

≥98% (HPLC)

form

powder

color

yellow to brown

mp

108-110 °C (lit.)

storage temp.

2-8°C

SMILES string

BrCC(=O)c1ccc(Br)cc1

InChI

1S/C8H6Br2O/c9-5-8(11)6-1-3-7(10)4-2-6/h1-4H,5H2

InChI key

FKJSFKCZZIXQIP-UHFFFAOYSA-N

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Structure of BthA-I complexed with p-bromophenacyl bromide: possible correlations with lack of pharmacological activity.

Angelo J Magro et al.

Acta crystallographica. Section D, Biological crystallography, 61(Pt 12), 1670-1677 (2005-11-23)

The crystal structure of an acidic phospholipase A(2) isolated from Bothrops jararacussu venom (BthA-I) chemically modified with p-bromophenacyl bromide (BPB) has been determined at 1.85 Angstroms resolution. The catalytic, platelet-aggregation inhibition, anticoagulant and hypotensive activities of BthA-I are abolished by

Catalytic activity-independent pathway is involved in phospholipase A(2)-induced apoptotic death of human leukemia U937 cells via Ca(2+)-mediated p38 MAPK activation and mitochondrial depolarization.

Wen-Hsin Liu et al.

Toxicology letters, 185(2), 102-109 (2009-01-03)

In view of the controversial role of catalytic activity on the cytotoxicity of phospholipase A(2) (PLA(2)), the present study is conducted to explore whether PLA(2) induces apoptotic process of human leukemia U937 cells through catalytic activity-independent pathway. Modification of His-48

Bothrops moojeni myotoxin-II, a Lys49-phospholipase A2 homologue: an example of function versatility of snake venom proteins.

Rodrigo G Stábeli et al.

Comparative biochemistry and physiology. Toxicology & pharmacology : CBP, 142(3-4), 371-381 (2006-01-31)

MjTX-II, a myotoxic phospholipase A(2) (PLA(2)) homologue from Bothrops moojeni venom, was functionally and structurally characterized. The MjTX-II characterization included: (i) functional characterization (antitumoral, antimicrobial and antiparasitic effects); (ii) effects of structural modifications by 4-bromophenacyl bromide (BPB), cyanogen bromide (CNBr)

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