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Merck
CN

B5311

Biperiden hydrochloride

≥98% (HPLC), powder

Synonym(s):

1-(5-Bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidinyl)propan-1-ol hydrochloride, Akineton, Akinophyl

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About This Item

Empirical Formula (Hill Notation):
C21H30ClNO
CAS Number:
1235-82-1
Molecular Weight:
347.92
PubChem Substance ID:
329773254
UNSPSC Code:
12352200
EC Number:
214-976-2
Assay:
≥98% (HPLC)
Form:
powder
Quality level:
100

Key Documents

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Quality Level

100

assay

≥98% (HPLC)

form

powder

color

off-white

solubility

DMSO: >20 mg/mL, H2O: insoluble

originator

Abbott

SMILES string

Cl[H].OC(CCN1CCCCC1)(C2CC3CC2C=C3)c4ccccc4

InChI

1S/C21H29NO.ClH/c23-21(19-7-3-1-4-8-19,11-14-22-12-5-2-6-13-22)20-16-17-9-10-18(20)15-17;/h1,3-4,7-10,17-18,20,23H,2,5-6,11-16H2;1H

InChI key

RDNLAULGBSQZMP-UHFFFAOYSA-N

Gene Information

human ... CHRM1(1128)

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Biochem/physiol Actions

Antiparkinsonian; non-selective muscarinic receptor antagonist.
Biperiden hydrochloride is antiparkinsonian; non-selective muscarinic receptor antagonist. It is used for the adjunctive treatment of all forms of Parkinson′s Disease (postencephalitic, idiopathic, and arteriosclerotic); also commonly used to improve parkinsonian signs and symptoms related to antipsychotic drug therapy. LD50 in rats 750 mg/kg; in dogs 340 mg/kg.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound is featured on the Acetylcholine Receptors (Muscarinic) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Abbott. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
051M4705V
037K47113
037K47112
037K47111
037K4711

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Marina S Zacarias et al.
Neuroscience letters, 513(2), 129-131 (2012-02-18)
It is well-known that cocaine dependence is a public health issue, and several studies stress the need to look for new and more effective treatments. Although the mesolimbic dopamine (DA) system, which originates in the ventral tegmental area (VTA) and
Use of anticholinergic drugs and worsening of pemphigus foliaceus in a patient with bipolar disorder.
Lúcio Botelho-Nogueira et al.
Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999), 33(4), 412-413 (2011-12-23)
Elmorsy Khaled et al.
Talanta, 87, 40-45 (2011-11-22)
The construction and performance characteristics of Biperiden (BP) polyvinyl chloride (PVC) electrodes are described. Different methods for electrode fabrication are tested including; incorporation of BP-ion pairs (BP-IPs), incorporation of ion pairing agents, or soaking the plain electrode in BP-ion pairs
Svjetlana Loga-Zec et al.
Psychiatria Danubina, 23(1), 60-63 (2011-03-31)
Polypharmacy in psychiatry is becoming the rule rather than the exception. Using more drugs at same time usually occurs where single drugs are considered insufficiently effective. The sample consisted of 216 patients: 85 from Sarajevo, and 44 and 87 respectively
Inge Klinkenberg et al.
The international journal of neuropsychopharmacology, 15(10), 1375-1385 (2011-11-19)
Learned irrelevance (LIrr) refers to a reduction in associative learning after pre-exposure of the conditioned and unconditioned stimulus in a non-contingent fashion. This paradigm might serve as a translational model for (pre)attentive information processing deficits in schizophrenia. This is the
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Articles

Muscarinic Acetylcholine Receptors

Muscarinic acetylcholine receptors mediate acetylcholine actions in CNS and non-nervous tissues, crucial for cell signaling.

Global Trade Item Number

SKUGTIN
B5311-10MG04061832079363

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