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Merck
CN

C2505

Corticosterone

≥92% (HPLC), powder, corticosteroid hormone

Synonym(s):

4-Pregnene-11β,21-diol-3,20-dione, 11β,21-Dihydroxy-4-pregnene-3,20-dione, 11β,21-Dihydroxyprogesterone, Kendall’s Compound B, Reichstein’s Substance H

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About This Item

Empirical Formula (Hill Notation):
C21H30O4
CAS Number:
50-22-6
Molecular Weight:
346.46
NACRES:
NA.77
PubChem Substance ID:
24278302
UNSPSC Code:
51111800
EC Number:
200-019-6
MDL number:
MFCD00037715
Beilstein/REAXYS Number:
2339601
Assay:
≥92%
Form:
powder
Quality level:
200

Key Documents

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Product Name

Corticosterone, ≥92%

biological source

synthetic (organic)

Quality Level

200

assay

≥92%

form

powder

mp

179-183 °C (lit.)

solubility

chloroform: 50 mg/mL, clear, colorless to faintly yellow

shipped in

ambient

storage temp.

room temp

SMILES string

C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@]34C)[C@@H]1CC[C@@H]2C(=O)CO

InChI

1S/C21H30O4/c1-20-8-7-13(23)9-12(20)3-4-14-15-5-6-16(18(25)11-22)21(15,2)10-17(24)19(14)20/h9,14-17,19,22,24H,3-8,10-11H2,1-2H3/t14-,15-,16+,17-,19+,20-,21-/m0/s1

InChI key

OMFXVFTZEKFJBZ-HJTSIMOOSA-N

Gene Information

human ... EBP(10682), SERPINA6(866)
rat ... Ar(24208), Nr3c1(24413)

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Application

Corticosterone has been used:
  • in chronic treatment to investigate its effect on somatostatin (SST) neurons in mice
  • as a stress inducing hormone in pregnant mice
  • to test its effect on depression-related behaviors in mice

Biochem/physiol Actions

Corticosterone is synthesized from 11-deoxycortisone by the action of enzyme 11β-hydroxylase majorly in adrenal glands. However, it may also be synthesized in non-adrenal tissues including leydig cells of testes and in murine thymus. Corticosterone is released post activation of hypothalamus-pituitary-adrenal (HPA) axis. It is a key player regulating metabolism, immune function and response to stress. It is produced by HPA activation in response to stress in myeloid cells. Elevated levels of corticosterone is observed in Huntington′s disease (HD).
Corticosterone is a glucocorticoid secreted by the adrenal cortex that activates both mineralocorticoid and glucocorticoid receptors.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000518802
0000518802
0000505212
0000505212
0000501136

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Amy E M Newman et al.
The Journal of comparative neurology, 518(18), 3662-3678 (2010-07-24)
Chronic elevations in glucocorticoids can decrease the production and survival of new cells in the adult brain. In rat hippocampus, supraphysiological doses of dehydroepiandrosterone (DHEA; a sex steroid precursor synthesized in the gonads, adrenals, and brain) have antiglucocorticoid properties. With
Glucocorticoid production in the chicken bursa and thymus
Lechner O, et al.
International Immunology, 13(6), 769-776 (2001)
Corticosterone dysregulation exacerbates disease progression in the R6/2 transgenic mouse model of Huntington's disease
Dufour BD and McBride JL
Experimental neurology, 283(9), 308-317 (2016)
Chronic stress alters concentrations of corticosterone receptors in a tissue-specific manner in wild house sparrows (Passer domesticus)
Lattin CR and Romero LM
The Journal of Experimental Biology, 217(14), 2601-2608 (2014)
Somatostatin, neuronal vulnerability and behavioral emotionality
Lin LC and Sibille E
Molecular Psychiatry, 20(3), 377-377 (2015)
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Global Trade Item Number

SKUGTIN
C2505-500MG04061835555840

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