C7041
McN-A-343
≥98% (TLC)
Synonym(s):
(4-Hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride, 4-[N-(3-Chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride
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About This Item
Empirical Formula (Hill Notation):
C14H18Cl2N2O2
CAS Number:
Molecular Weight:
317.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
color
off-white
solubility
H2O: soluble, ethanol: soluble
SMILES string
[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1
InChI
1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
InChI key
CXFZFEJJLNLOTA-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
rat ... Chrm1(25229)
Biochem/physiol Actions
M1 muscarinic acetylcholine receptor agonist.
Preparation Note
Solutions may be stored for several days at 4 °C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Laura Oliveira et al.
Neuro-Signals, 14(5), 262-272 (2005-11-23)
At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C
Hinako Suga et al.
Molecular pharmacology, 78(4), 745-755 (2010-07-21)
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this
Frederick J Mitchelson
Pharmacology & therapeutics, 135(2), 216-245 (2012-05-31)
The unusual pharmacology of McN-A-343 was first described by Roszowski in 1961. The agonist appeared to be a selective stimulant of muscarinic receptors in sympathetic ganglia, now known to be the muscarinic M₁ receptor subtype. However, subsequent research demonstrated that
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7041-25MG | 04061833511862 |
| C7041-100MG | 04061833511855 |