C7041
McN-A-343
≥98% (TLC)
Synonym(s):
(4-Hydroxy-2-butynyl)-1-trimethylammonium-3-chlorocarbanilate chloride, 4-[N-(3-Chlorophenyl)carbamoyloxy]-2-butynyltrimethylammonium chloride
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About This Item
Empirical Formula (Hill Notation):
C14H18Cl2N2O2
CAS Number:
Molecular Weight:
317.21
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
MDL number:
Quality Level
assay
≥98% (TLC)
form
powder
color
off-white
solubility
H2O: soluble, ethanol: soluble
SMILES string
[Cl-].C[N+](C)(C)CC#CCOC(=O)Nc1cccc(Cl)c1
InChI
1S/C14H17ClN2O2.ClH/c1-17(2,3)9-4-5-10-19-14(18)16-13-8-6-7-12(15)11-13;/h6-8,11H,9-10H2,1-3H3;1H
InChI key
CXFZFEJJLNLOTA-UHFFFAOYSA-N
Gene Information
human ... CHRM1(1128), CHRM2(1129), CHRM3(1131), CHRM4(1132), CHRM5(1133)
rat ... Chrm1(25229)
Biochem/physiol Actions
M1 muscarinic acetylcholine receptor agonist.
Preparation Note
Solutions may be stored for several days at 4 °C.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Lauren T May et al.
Molecular pharmacology, 72(2), 463-476 (2007-05-26)
The M2 muscarinic acetylcholine receptor (mAChR) possesses at least one binding site for allosteric modulators that is dependent on the residues (172)EDGE(175), Tyr(177), and Thr(423). However, the contribution of these residues to actions of allosteric agonists, as opposed to modulators
Hinako Suga et al.
Molecular pharmacology, 78(4), 745-755 (2010-07-21)
Investigating how a test drug alters the reaction of a site-directed electrophile with a receptor is a powerful method for determining whether the drug acts competitively or allosterically, provided that the binding site of the electrophile is known. In this
Laura Oliveira et al.
Neuro-Signals, 14(5), 262-272 (2005-11-23)
At the rat motor endplate, pre-synaptic facilitatory adenosine A2A and muscarinic M1 receptors are mutually exclusive. We investigated whether these receptors share a common intracellular signalling pathway. Suppression of McN-A-343-induced M1 facilitation of [3H]ACh release was partially recovered when CGS21680C
Global Trade Item Number
| SKU | GTIN |
|---|---|
| C7041-25MG | 04061833511862 |
| C7041-100MG | 04061833511855 |