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Merck
CN

C8895

Clofazimine

≥98% (TLC), powder, antimycobacterial rimonphenazine

Synonym(s):

N,5-Bis(4-chlorophenyl)-3,5-dihydro-3-(isopropylimino)phenazin-2-amine

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About This Item

Empirical Formula (Hill Notation):
C27H22Cl2N4
CAS Number:
2030-63-9
Molecular Weight:
473.40
NACRES:
NA.77
PubChem Substance ID:
24893114
UNSPSC Code:
12352200
EC Number:
217-980-2
MDL number:
MFCD00056793
Form:
powder
Quality level:
200

Key Documents

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Product Name

Clofazimine,

form

powder

Quality Level

200

antibiotic activity spectrum

mycobacteria

mode of action

protein synthesis | interferes

originator

Novartis

SMILES string

CC(C)\N=C1/C=C2N(c3ccc(Cl)cc3)c4ccccc4N=C2C=C1Nc5ccc(Cl)cc5

InChI

1S/C27H22Cl2N4/c1-17(2)30-24-16-27-25(15-23(24)31-20-11-7-18(28)8-12-20)32-22-5-3-4-6-26(22)33(27)21-13-9-19(29)10-14-21/h3-17,31H,1-2H3/b30-24+

InChI key

WDQPAMHFFCXSNU-BGABXYSRSA-N

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General description

Clofazimine is a riminophenazine, which is used as an antileprosy drug. It is used to treat multidrug-resistant tuberculosis. Clofazimine prevents neutrophil motility and lymphocyte transformation. It has anti-inflammatory effect, which is used to treat discoid lupus erythematosus. Clofazimine has immunosuppressive property.

Application

Clofazimine has been used:
  • for antimicrobial preparation
  • to study its accumulation on macrophages to form crystal-like drug inclusions (CLDIs)
  • to model drug-induced hepatic granulomatous inflammation
  • to study the in vivo cargo storage capacity of macrophages

Features and Benefits

This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is stored at room temperature.

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

涉药品监管产品

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Certificates of Analysis (COA)

Lot/Batch Number
0000539225
0000539224
0000539225
0000539224
0000509360

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Jakko van Ingen et al.
Antimicrobial agents and chemotherapy, 56(12), 6324-6327 (2012-10-03)
Disease caused by nontuberculous mycobacteria (NTM) is increasing in frequency. The outcome of treatment for NTM lung disease is poor, particularly lung disease caused by Mycobacterium simiae and M. abscessus. Exploring synergy between active available drugs is a sensible way
An Expandable Mechanopharmaceutical Device (2): Drug Induced Granulomas Maximize the Cargo Sequestering Capacity of Macrophages in the Liver
Rzeczycki P, et al.
Pharmaceutical Research, 36(1), 3-3 (2019)
Detecting ordered small molecule drug aggregates in live macrophages: a multi-parameter microscope image data acquisition and analysis strategy
Rzeczycki P, et al.
Biomedical Optics Express, 8(2), 860-872 (2017)
Jacques H Grosset et al.
American journal of respiratory and critical care medicine, 188(5), 608-612 (2013-07-05)
Although observational studies suggest that clofazimine-containing regimens are highly active against drug-resistant tuberculosis, the contribution of clofazimine for the treatment of this disease has never been systematically evaluated. Our goal was to directly compare the activity of a standard second-line
Plumb's Veterinary Drug Handbook (2008)
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Global Trade Item Number

SKUGTIN
C8895-1G04061833522981
C8895-5G04061833522998

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