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D6035

Disopyramide phosphate salt

Name: Disopyramide phosphate salt
Brand: SIGMA

Synonym(s):

α-Diisopropylaminoethyl-α-phenylpyridine-2-acetamide

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About This Item

Linear Formula:

C₂₁H₂₉N₃O · H₃PO₄

CAS Number:

22059-60-5

Molecular Weight:

437.47

NACRES:

NA.77

PubChem Substance ID:

24277706

UNSPSC Code:

12352200

EC Number:

244-756-1

MDL number:

MFCD00069254

Form:

solid

Quality level:

200

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Properties

form

solid

Quality Level

200

SMILES string

OP(O)(O)=O.CC(C)N(CCC(C(N)=O)(c1ccccc1)c2ccccn2)C(C)C

InChI

1S/C21H29N3O.H3O4P/c1-16(2)24(17(3)4)15-13-21(20(22)25,18-10-6-5-7-11-18)19-12-8-9-14-23-19;1-5(2,3)4/h5-12,14,16-17H,13,15H2,1-4H3,(H2,22,25);(H3,1,2,3,4)

InChI key

CGDDQFMPGMYYQP-UHFFFAOYSA-N

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Description

Application

Disopyramide phosphate salt has been used as an internal standard for plasma sample analysis by mass spectrometry. It might be used as a test compound in a teratogenicity study.

Biochem/physiol Actions

Disopyramide is found to stabilize the cell membrane by altering the action potential. It might act as an antiarrhythmic agent.

Class IA antiarrhythmic; sodium channel blocker

pictograms

GHS07

signalword

Warning

hcodes

H302

pcodes

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

ppe

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number

0000484047

018F0560

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Drugs for Pregnant and Lactating Women, 252-338 (2009)

Improvement of the evaluation method for teratogenicity using zebrafish embryos.

Akihito Yamashita et al.

The Journal of toxicological sciences, 39(3), 453-464 (2014-05-23)

The zebrafish has been considered as a suitable animal model for drug discovery, especially for evaluation of the teratogenicity, due to their small size, rapid development, transparency, and developmental similarities to mammalian development. These features of zebrafish make it possible

The relationship of clinical QT prolongation to outcome in the conscious dog using a beat-to-beat QT-RR interval assessment.

Anthony A Fossa et al.

The Journal of pharmacology and experimental therapeutics, 302(2), 828-833 (2002-07-20)

QT interval prolongation of the electrocardiogram has been associated with the occurrence of life-threatening fatal ventricular arrhythmias. To understand the relationship between preclinical cardiac conduction assessment to clinical outcome, comparisons of free (unbound)-plasma drug concentrations and their associated effects in

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Global Trade Item Number

SKU	GTIN
D6035-10G	04061832574318
D6035-1G	04061826226070