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Merck
CN

D6413

Diloxanide furoate

Synonym(s):

2,2-Dichloro-N-(4-hydroxyphenyl)-N-methylacetamide 2-furoic acid ester

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About This Item

Empirical Formula (Hill Notation):
C14H11Cl2NO4
CAS Number:
Molecular Weight:
328.15
UNSPSC Code:
51101500
PubChem Substance ID:
EC Number:
223-108-1
MDL number:
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antibiotic activity spectrum

parasites

SMILES string

CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1

InChI

1S/C14H11Cl2NO4/c1-17(13(18)12(15)16)9-4-6-10(7-5-9)21-14(19)11-3-2-8-20-11/h2-8,12H,1H3

InChI key

BDYYDXJSHYEDGB-UHFFFAOYSA-N

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Tsukasa Fujishima et al.
Chemotherapy, 56(4), 348-352 (2010-08-20)
A mass Entamoeba histolytica infection recurred despite repeated treatments with metronidazole at a rehabilitation institution for individuals with intellectual impairments. Diloxanide furoate was administered to improve intractable intestinal amoebiasis after a recurring amoebic infection that tends to occur via coprophagy
Treatment of asymptomatic intestinal Entamoeba histolytica infection.
Joerg Blessmann et al.
The New England journal of medicine, 347(17), 1384-1384 (2002-10-25)
Cecal ameboma.
Deepak Joshi et al.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 8(1), A28-A28 (2009-03-14)
E Schwartz et al.
Journal of travel medicine, 5(2), 95-96 (1998-10-17)
Hepatitis A virus (HAV) infection and amoebic liver abscess have an identical mode of transmission (fecal-oral route) and similar epidemiology. Either of these diseases might be considered in patients presenting with clinical signs and symptoms of liver disease in areas
Asteria Luzardo Álvarez et al.
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences, 47(1), 215-227 (2012-06-20)
We present a new strategy to suppress the attachment of Cryptosporidium parvum to the enterocytes cell surface by bioadhesive microspheres. An optimized microsphere system based on chitosan/poly(vinyl alcohol) was prepared by experimental design for the delivery of Diloxanide Furoate-cyclodextrin complex.

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