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Merck
CN

D7285

3′-Deoxyguanosine

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About This Item

Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
Molecular Weight:
267.24
UNSPSC Code:
41106305
PubChem Substance ID:
MDL number:
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biological source

synthetic (organic)

assay

≥98% (HPLC)

form

powder

solubility

1 M NH4OH: 50 mg/mL, clear, colorless

SMILES string

NC1=NC(=O)c2ncn(C3OC(CO)CC3O)c2N1

InChI

1S/C10H13N5O4/c11-10-13-7-6(8(18)14-10)12-3-15(7)9-5(17)1-4(2-16)19-9/h3-5,9,16-17H,1-2H2,(H3,11,13,14,18)

InChI key

OROIAVZITJBGSM-UHFFFAOYSA-N

Application

3′-Deoxyguanosine (3dG) is used as a complexing ligand for enzymes, such as purine nucleoside phosphorylase (PNP), and receptors, such as G-coupled receptors, to enable structure analysis. 3′-Deoxyguanosine may be used to selectively impair transcription but not polyadenylation.


Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Ugo Traversa et al.
Bioorganic & medicinal chemistry, 11(24), 5417-5425 (2003-12-04)
Rat brain guanosine binding sites were studied by (i). a pharmacological approach to confirm the hypothesis of the existence of specific G-coupled receptors for guanosine (1) and, for the first time, delineate a structure-activity relationship for a series of guanosine
Juan M Traverso et al.
Molecular reproduction and development, 71(1), 107-114 (2005-03-01)
The control of protein synthesis during maturation in oocytes is mainly exerted through cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status of cyclins A2 and B1 during in vitro maturation (IVM) of bovine oocytes, using Rapid Amplification
Robert W King et al.
Antiviral chemistry & chemotherapy, 13(6), 363-370 (2003-04-30)
The development of low molecular weight inhibitors of hepatitis C virus (HCV) replication has been hindered by the lack of a good cell-based system that models the entire HCV replication cycle. To date the only two therapies approved for the