D7285
3′-Deoxyguanosine
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About This Item
Empirical Formula (Hill Notation):
C10H13N5O4
CAS Number:
Molecular Weight:
267.24
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
biological source
synthetic (organic)
Assay
≥98% (HPLC)
form
powder
solubility
1 M NH4OH: 50 mg/mL, clear, colorless
SMILES string
NC1=NC(=O)c2ncn(C3OC(CO)CC3O)c2N1
InChI
1S/C10H13N5O4/c11-10-13-7-6(8(18)14-10)12-3-15(7)9-5(17)1-4(2-16)19-9/h3-5,9,16-17H,1-2H2,(H3,11,13,14,18)
InChI key
OROIAVZITJBGSM-UHFFFAOYSA-N
Application
3′-Deoxyguanosine (3dG) is used as a complexing ligand for enzymes, such as purine nucleoside phosphorylase (PNP), and receptors, such as G-coupled receptors, to enable structure analysis. 3′-Deoxyguanosine may be used to selectively impair transcription but not polyadenylation.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Ugo Traversa et al.
Bioorganic & medicinal chemistry, 11(24), 5417-5425 (2003-12-04)
Rat brain guanosine binding sites were studied by (i). a pharmacological approach to confirm the hypothesis of the existence of specific G-coupled receptors for guanosine (1) and, for the first time, delineate a structure-activity relationship for a series of guanosine
Juan M Traverso et al.
Molecular reproduction and development, 71(1), 107-114 (2005-03-01)
The control of protein synthesis during maturation in oocytes is mainly exerted through cytoplasmic polyadenylation of stored mRNAs. We first analyzed the polyadenylation status of cyclins A2 and B1 during in vitro maturation (IVM) of bovine oocytes, using Rapid Amplification
Robert W King et al.
Antiviral chemistry & chemotherapy, 13(6), 363-370 (2003-04-30)
The development of low molecular weight inhibitors of hepatitis C virus (HCV) replication has been hindered by the lack of a good cell-based system that models the entire HCV replication cycle. To date the only two therapies approved for the
Tohru Ikegami et al.
Journal of chromatography. A, 1638, 461850-461850 (2021-01-23)
Herein, commercially available columns employed in hydrophilic interaction chromatography (HILIC) were characterized by determining their ability to selectively distinguish the minute structural differences between small molecules such as nucleosides and xanthines in complex sample matrices. Principal component analysis (PCA) was
Fernanda Canduri et al.
Acta crystallographica. Section D, Biological crystallography, 61(Pt 7), 856-862 (2005-06-29)
Purine nucleoside phosphorylase (PNP) is a key enzyme in the purine-salvage pathway, which allows cells to utilize preformed bases and nucleosides in order to synthesize nucleotides. PNP is specific for purine nucleosides in the beta-configuration and exhibits a strong preference
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