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Merck
CN

E0276

EPPS

BioPerformance Certified, suitable for cell culture, ≥99.5% (titration)

Synonym(s):

4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid, 4-(2-Hydroxyethyl)piperazine-1-propanesulfonic acid, N-(2-Hydroxyethyl)piperazine-N′-(3-propanesulfonic acid), HEPPS

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About This Item

Empirical Formula (Hill Notation):
C9H20N2O4S
CAS Number:
16052-06-5
Molecular Weight:
252.33
UNSPSC Code:
12161700
NACRES:
NA.25
PubChem Substance ID:
24894366
EC Number:
240-198-8
Beilstein/REAXYS Number:
3957385
MDL number:
MFCD00006160

Key Documents

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grade

BioPerformance Certified

Quality Level

400

assay

≥99.5% (titration)

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin and Total Aerobic Microbial Count, tested

pH

7.3-8.7

useful pH range

7.3-8.7

pKa (25 °C)

8.0

pKa 

8

mp

237-239 °C (lit.)

solubility

H2O: 25 g + 50 mL, clear, colorless

cation traces

heavy metals (as Pb): ≤5 ppm

λmax

A290 at ≤0.1 (C=33% w/w)

application(s)

diagnostic assay manufacturing

SMILES string

OCCN1CCN(CCCS(O)(=O)=O)CC1

InChI

1S/C9H20N2O4S/c12-8-7-11-5-3-10(4-6-11)2-1-9-16(13,14)15/h12H,1-9H2,(H,13,14,15)

InChI key

OWXMKDGYPWMGEB-UHFFFAOYSA-N

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General description

EPPS or 4-(2-hydroxyethyl)piperazine-1-propanesulfonic acid (HEPPS) is a zwitterionic buffer substance from the group of good buffers. It effectively maintains constant pH in a solution, which is necessary for many biological and biochemical reactions. EPPS buffer is widely used in cell culture experiments and biological research.

Application

EPPS may be used as a buffer solution to stabilize the pH in sea water samples during the titration experiments.

Features and Benefits

  • BioPerformance Certified, high-quality level (400), ensures reliable and consistent results.
  • Suitable for mammalian cell culture techniques

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000525700
0000525700
0000430311
0000430311
0000414531

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The characteristics of Fe speciation and Fe-binding ligands in the Mariana back-arc hydrothermal plumes
Wang H R, et al.
Geochimica et Cosmochimica Acta, 292, 24-36 (2021)
Equilibrium studies, synthesis, and characterization of zwitterionic buffer (HEPES and HEPPS) dimethyltin (IV) complexes
Mahmoud M, et al.
Main Group Chemistry, 6(2) (2007)
lonization Enthalpies of Some Common Zvvitterionic Hydrogen-lon Buffers (HEPES, PIPES, HEPPS and BES) for Biological Research
Roig T, et al.
Journal of Separation Science, 993(47), 899-90j-899-90j (1993)
Feng Xie et al.
Cancer letters, 364(2), 106-117 (2015-05-17)
Cervical cancer is often associated with eosinophil (EOS) infiltration, but the source and the role of EOS are still largely unknown. Our previous work has established that thymic stromal lymphopoietin (TSLP) can stimulate the growth of cervical cancer cell in
Xiannu Jin et al.
Journal of pharmacological and toxicological methods, 70(2), 188-194 (2014-08-26)
Malaria is a major health concern and affects over 300million people a year. Accordingly, there is an urgent need for new efficacious anti-malarial drugs. A major challenge in developing new anti-malarial drugs is to design active molecules that have preferable
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Global Trade Item Number

SKUGTIN
E0276-500G04061833619704
E0276-25G04061833512289
E0276-100G04061833610657

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