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Merck
CN

E2625

(+)-Pseudoephedrine

Synonym(s):

(+)-ψ-Ephedrine, (1S,2S)-2-Methylamino-1-phenyl-1-propanol, d-Isoephedrine, d-Pseudoephedrine

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About This Item

Empirical Formula (Hill Notation):
C10H15NO
CAS Number:
90-82-4
Molecular Weight:
165.23
EC Number:
202-018-6
UNSPSC Code:
41116107
MDL number:
MFCD00064256
Beilstein/REAXYS Number:
2414132

Key Documents

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grade

analytical standard

technique(s)

HPLC: suitable, gas chromatography (GC): suitable

mp

118-120 °C

format

neat

SMILES string

CN[C@@H](C)[C@@H](O)c1ccccc1

InChI

1S/C10H15NO/c1-8(11-2)10(12)9-6-4-3-5-7-9/h3-8,10-12H,1-2H3/t8-,10+/m0/s1

InChI key

KWGRBVOPPLSCSI-WCBMZHEXSA-N

Application

(+)-Pseudoephedrine may be used as a reference standard in the determination of pseudoephedrine in pharmaceutical formulations using high performance thin layer chromatography (HPTLC).
Refer to the product′s Certificate of Analysis for more information on a suitable instrument technique. Contact Technical Service for further support.

Biochem/physiol Actions

Non-selective adrenergic agonist; decongestant

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
129H2608
117F0076
107F0269
089H2601
086F0441

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Stability indicating HPTLC method for the simultaneous determination of pseudoephedrine and cetirizine in pharmaceutical formulations.
Makhija N S and Vavia R P.
Journal of Pharmaceutical and Biomedical Analysis, 25(3-4), 663-667 (2001)
Pablo Vazquez-Roig et al.
The Science of the total environment, 494-495, 49-57 (2014-07-17)
The enantiomeric and diastereomeric profiling of chiral pharmaceuticals (ephedrine, norephedrine, atenolol and venlafaxine) and illicit drugs (amphetamine, methamphetamine, 3,4-methylenedioxyamphetamine (MDA), 3,4-methylenedioxy-N-methylamphetamine (MDMA) and 3,4-methylenedioxy-N-ethylamphetamine (MDEA)) was undertaken over a period of fourteen consecutive days in three wastewater treatment plants (WWTPs)
Sian E Evans et al.
Analytica chimica acta, 882, 112-126 (2015-06-05)
This is the first study presenting a multi-residue method allowing for comprehensive analysis of several chiral pharmacologically active compounds (cPACs) including beta-blockers, antidepressants and amphetamines in wastewater and digested sludge at the enantiomeric level. Analysis of both the liquid and
Sara Odoardi et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 1000, 57-68 (2015-07-26)
The increasing number of new psychoactive substances (NPS) present in the illicit market render their identification in biological fluids/tissues of great concern for clinical and forensic toxicology. Analytical methods able to detect the huge number of substances that can be
Aurélie Periat et al.
Journal of chromatography. A, 1356, 211-220 (2014-07-16)
In this study, the influence of electrospray ionization (ESI) source design on the overall sensitivity achieved in hydrophilic interaction chromatography (HILIC) and reversed phase liquid chromatography (RPLC), was investigated. State-of-the-art triple quadrupole mass analyzers from AB Sciex, Agilent Technologies and
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