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F112

(+)-Fenfluramine hydrochloride

Name: (+)-Fenfluramine hydrochloride
Brand: SIGMA

serotonin uptake inhibitor, powder

Synonym(s):

(+)-N-Ethyl-α-methyl-m-[trifluoromethyl]phenethylamine hydrochloride, Dexfenfluramine hydrochloride

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About This Item

Empirical Formula (Hill Notation):

C₁₂H₁₆F₃N · HCl

CAS Number:

3239-45-0

Molecular Weight:

267.72

NACRES:

NA.77

PubChem Substance ID:

24894746

UNSPSC Code:

12352116

EC Number:

221-806-0

MDL number:

MFCD00069276

Form:

powder

Quality level:

200

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Product Name

(+)-Fenfluramine hydrochloride,

form

powder

Quality Level

200

drug control

USDEA Schedule IV

color

white to off-white

solubility

H₂O: soluble 10 mg/mL

application(s)

forensics and toxicology

storage temp.

room temp

SMILES string

Cl[H].CCN[C@@H](C)Cc1cccc(c1)C(F)(F)F

InChI

1S/C12H16F3N.ClH/c1-3-16-9(2)7-10-5-4-6-11(8-10)12(13,14)15;/h4-6,8-9,16H,3,7H2,1-2H3;1H/t9-;/m0./s1

InChI key

ZXKXJHAOUFHNAS-FVGYRXGTSA-N

Gene Information

human ... HTR1A(3350), HTR1B(3351), HTR1D(3352), HTR1E(3354), HTR1F(3355), HTR2A(3356), HTR2B(3357), HTR2C(3358), HTR3A(3359), HTR3B(9177), HTR3C(170572), HTR3D(200909), HTR3E(285242), HTR4(3360), HTR5A(3361), HTR6(3362), HTR7(3363)

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Biochem/physiol Actions

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic.

(+)-Fenfluramine is a serotonin uptake inhibitor; anoxexic. (+)-Fenfluramine is neurotoxic on prolonged administration or at high dosage. (+)-Fenfluramine releases serotonin from axon terminals by a nonexocytotic mechanism.

Other Notes

Active isomer

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331

pcodes

P261 - P264 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

Regulatory Information

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Influence of fenfluramine and norfenfluramine stereoisomers on the firing rate of central monoaminergic neurons in the rat.

J Scuvée-Moreau et al.

European journal of pharmacology, 179(1-2), 211-215 (1990-04-10)

The influence of acute administration of stereoisomers of fenfluramine and norfenfluramine on the firing rate of central monoaminergic neurons was investigated in rats anaesthetized with chloral hydrate. The firing rate of dorsal raphe (DR) and locus coeruleus (LC) neurons was

Dexfenfluramine discontinuous treatment does not worsen hypoxia-induced pulmonary vascular remodeling but activates RhoA/ROCK pathway: consequences on pulmonary hypertension.

Nicolas Desbuards et al.

European journal of pharmacology, 602(2-3), 355-363 (2008-12-04)

The anorectic drug, dexfenfluramine has been associated with an increase in the relative risk of developing pulmonary hypertension. 5-hydroxytryptamine (5-HT) is a mitogen for smooth muscle cell, an effect that relies on 5-HT transporter expression and which has been proposed

Metabolic and practical considerations on microbial electrosynthesis.

Korneel Rabaey et al.

Current opinion in biotechnology, 22(3), 371-377 (2011-03-01)

The production of biofuels and biochemicals is highly electron intensive. To divert fermentative and respiratory pathways to the product of interest, additional electrons (i.e. reducing power) are often needed. Meanwhile, the past decade has seen the breakthrough of sustainable electricity

Pulmonary arterial hypertension in a patient with Cowden syndrome and anorexigen exposure.

Delphine Natali et al.

Chest, 140(4), 1066-1068 (2011-10-06)

We report a case of pulmonary arterial hypertension (PAH) occurring in a patient with Cowden syndrome with a mutation in the phosphatase and tensin (PTEN) tumor suppressor gene, in the context of exposure to the appetite suppressant dexfenfluramine. Anorexigen exposure

The serotonin hypothesis of pulmonary hypertension revisited.

Margaret R Maclean et al.

Advances in experimental medicine and biology, 661, 309-322 (2010-03-06)

The serotonin hypothesis of pulmonary arterial hypertension (PAH) arose after an outbreak of PAH in patients taking the anorexigenic drugs aminorex and dexfenfluramine. Both of these drugs are serotonin transporter (SERT) substrates and indirect serotinergic agonists. There is now a

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Global Trade Item Number

SKU	GTIN
F112-25MG	04061832556536
F112-100MG	04061833611654

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