F8257
Flunarizine dihydrochloride
≥98% (TLC), T-type Ca2+/Na+ channel blocker
Synonym(s):
1-[Bis(4-fluorophenyl)methyl]-4-(3-phenyl-2-propenyl)piperazine dihydrochloride
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About This Item
Empirical Formula (Hill Notation):
C26H26F2N2 · 2HCl
CAS Number:
Molecular Weight:
477.42
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
250-216-6
MDL number:
Beilstein/REAXYS Number:
4284243
Assay:
≥98% (TLC)
Quality level:
Product Name
Flunarizine dihydrochloride, ≥98% (TLC)
Quality Level
assay
≥98% (TLC)
originator
Johnson & Johnson
storage temp.
2-8°C
SMILES string
Cl[H].Cl[H].Fc1ccc(cc1)C(N2CCN(CC2)C\C=C\c3ccccc3)c4ccc(F)cc4
InChI
1S/C26H26F2N2.2ClH/c27-24-12-8-22(9-13-24)26(23-10-14-25(28)15-11-23)30-19-17-29(18-20-30)16-4-7-21-5-2-1-3-6-21;;/h1-15,26H,16-20H2;2*1H/b7-4+;;
InChI key
RXKMOPXNWTYEHI-RDRKJGRWSA-N
General description
Flunarizine has antihistamine, anticonvulsant and vestibular depressive properties. It protects endothelial cells from calcium overload-induced damage. Flunarizine is used to treat epilepsy, migraine prophylaxis, cerebral blood flow disturbances, peripheral vascular disease and vertigo.
Application
Flunarizine dihydrochloride has been used to study the effect of flunarizine on epileptiform activity. It is also used to study its effect on high-potassium induced increase of intracellular free calcium.
Biochem/physiol Actions
Blocks T-type Ca2+/Na+ channels.
Blocks T-type Ca2+/Na+ channels; inhibits K+-induced catecholamine release from chromaffin cells
Features and Benefits
This compound was developed by Johnson & Johnson. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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The effect of flunarizine on penicillin model epilepsy in rats
BAGIRICI F, et al.
Journal of Experimental and Clinical Medicine, 16(4) (1999)
Effects of flunarizine on induced calcium transients as measured in fura-2-loaded neurons of the rat dorsal root ganglion
Leybaert L, et al.
Naunyn-Schmiedeberg'S Archives of Pharmacology, 348(3), 269-274 (1993)
Double-blind placebo-controlled trial of flunarizine as add-on therapy in epilepsy
Overweg J, et al.
Epilepsia, 25(2), 217-222 (1984)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| F8257-1G | 04061833620410 |
| F8257-10G | 04061832961637 |