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H1635

N-Hippuryl-His-Leu hydrate

Name: N-Hippuryl-His-Leu hydrate
Brand: SIGMA

chromogenic, ≥98% (HPLC), powder

Synonym(s):

N-Benzoyl-Gly-His-Leu, N-Hippuryl-L-histidyl-L-leucine hydrate

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About This Item

Empirical Formula (Hill Notation):

C₂₁H₂₇N₅O₅ · xH₂O

CAS Number:

207386-83-2

Molecular Weight:

429.47 (anhydrous basis)

NACRES:

NA.32

PubChem Substance ID:

24895469

UNSPSC Code:

12352204

EC Number:

250-597-9

MDL number:

MFCD00149318

Beilstein/REAXYS Number:

5664178

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Properties

Product Name

N-Hippuryl-His-Leu hydrate, powder, ≥98% (HPLC)

Quality Level

200

assay

≥98% (HPLC)

form

powder

color

white to off-white

solubility

acetic acid: ~50 mg/mL

storage temp.

−20°C

SMILES string

O.CC(C)C[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)c2ccccc2)C(O)=O

InChI

1S/C21H27N5O5.H2O/c1-13(2)8-17(21(30)31)26-20(29)16(9-15-10-22-12-24-15)25-18(27)11-23-19(28)14-6-4-3-5-7-14;/h3-7,10,12-13,16-17H,8-9,11H2,1-2H3,(H,22,24)(H,23,28)(H,25,27)(H,26,29)(H,30,31);1H2/t16-,17-;/m0./s1

InChI key

NWOJMNXIJBZMPK-QJHJCNPRSA-N

Gene Information

human ... ACE(1636), ACE2(59272)
mouse ... ACE3(217246)
rat ... ACE(11421), ACE2(70008), ACE3(498012)

Description

General description

Substrate for angiotensin converting enzyme.

Application

N-Hippuryl-His-Leu hydrate has been used in the measurement of angiotensin-converting enzyme (ACE) inhibitory activity using oyster hydrolysates, semimembranosus muscle samples, and rabbit lung acetone powder.

Biochem/physiol Actions

N-Hippuryl-His-Leu hydrate (HHL) can be used as an artificial substrate for angiotensin-converting enzyme (ACE).

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Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number

0000506150

0000506157

0000506156

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Characterization and ACE-inhibitory activity of amaranth proteins.

A Tiengo et al.

Journal of food science, 74(5), H121-H126 (2009-08-04)

Amaranth seeds have been considered as an excellent alternative or complementary source of food protein due to their balanced amino acid composition. However, their potential as a source of bioactive peptides has not been explored. The present study is aimed

In Silico Elucidation of the Molecular Recognition of Phenol Derivative Compounds and Hippuryl-histidyl-leucine as an Artificial Substrate with the Experimental Target: Angiotensin-converting Enzyme

Vazquez-Valaldez VH, et al.

Letters in Drug Design & Discovery (2020)

Prolonged atrial natriuretic peptide exposure stimulates guanylyl cyclase-a degradation.

Darcy R Flora et al.

Endocrinology, 151(6), 2769-2776 (2010-04-13)

Natriuretic peptide receptor-A (NPR-A), also known as guanylyl cyclase-A, is a transmembrane receptor guanylyl cyclase that is activated by the cardiac hormones atrial natriuretic peptide and B-type natriuretic peptide. Although ligand-dependent NPR-A degradation (also known as down-regulation) is widely acknowledged

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Global Trade Item Number

SKU	GTIN
H1635-100MG	04061835545438
H1635-500MG	04061835512607
H1635-25MG	04061835557080
H1635-1G	04061833672686