H6382
Hydroxyethyl starch
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About This Item
CAS Number:
NACRES:
NA.25
PubChem Substance ID:
UNSPSC Code:
12352201
MDL number:
biological source
maize
form
powder
SMILES string
OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O.OCCOC[C@H]2O[C@H](OCCO)[C@H](OCCO)[C@@H](OCCO)[C@@H]2OCCO
InChI
1S/C16H32O11.C6H12O6/c17-1-6-22-11-12-13(23-7-2-18)14(24-8-3-19)15(25-9-4-20)16(27-12)26-10-5-21;7-1-2-3(8)4(9)5(10)6(11)12-2/h12-21H,1-11H2;2-11H,1H2/t12-,13-,14+,15-,16+;2-,3-,4+,5-,6+/m11/s1
InChI key
DNZMDASEFMLYBU-RNBXVSKKSA-N
General description
Hydroxyethyl starch is a non-ionic starch derivative. It is categorized based on its in vitro molecular weight. A 6% concentration is commonly preferred with 130 kD and 0.38 to 0.45 of molecular weight and molar substitution ratios respectively. Degree of substitution; Average of 1 -OH group per 10 glucose units converted to -OCH2CH2OH.
Application
Hydroxyethyl starch has been used to study its shear response. It has also been used as a macromolecular compound in the medium for sperm isolation, culture and cryopreservation.
Biochem/physiol Actions
Hydroxyethyl starch (HES) is a colloid used for medicinal practices that involve fluid replacement. It acts as a plasma substitute. Acute kidney failure risk is increased by the use of HES in patients with severe sepsis.
Preparation Note
Prepared from corn starch
Other Notes
The similar Hetastarch (q.v.) is substituted to the extent of 7-8 groups per 10 glucose units.
Storage Class
13 - Non Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Hydroxyethyl starch or saline for fluid resuscitation in intensive care
Myburgh JA
The New England Journal of Medicine, 367(20), 1901-1911 (2012)
Hydroxyethyl starch 130/0.42 versus Ringer's acetate in severe sepsis
Perner A, et al.
The New England Journal of Medicine, 367(2), 124-134 (2012)
Shear-thickening fluids in biologically relevant agents
Kilbride P, et al.
Biorheology, 25(Preprint), 1-12 (2019)
An international view of hydroxyethyl starches
Treib J, et al.
Intensive Care Medicine, 25(3), 258-268 (1999)
A preliminary search for alternatives to albumin as a medium supplement for the culture of human sperm
Matson P and Tardif S
Reproductive Biology, 12(3), 329-331 (2012)
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