H7270
HC toxin from Helminthosporium carbonum
lyophilized powder
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About This Item
Empirical Formula (Hill Notation):
C21H32N4O6
CAS Number:
Molecular Weight:
436.50
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Assay:
90-95% (TLC)
Form:
lyophilized powder
assay
90-95% (TLC)
form
lyophilized powder
storage temp.
2-8°C
SMILES string
CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O
InChI
1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)
InChI key
GNYCTMYOHGBSBI-UHFFFAOYSA-N
Biochem/physiol Actions
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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J W Pitkin et al.
Microbiology (Reading, England), 142 ( Pt 6), 1557-1565 (1996-06-01)
Race 1 isolates of Cochliobolus carbonum are pathogenic on certain maize lines due to production of a host-selective cyclic tetrapeptide, HC-toxin. Flanking HTS1, which encodes the central enzyme in HC-toxin biosynthesis, a gene was identified and named TOXA. Like HTS1
Dipnath Baidyaroy et al.
Eukaryotic cell, 1(4), 538-547 (2002-11-29)
HC-toxin, a cyclic peptide made by the filamentous fungus Cochliobolus carbonum, is an inhibitor of histone deacetylase (HDAC) from many organisms. It was shown earlier that the HDAC activity in crude extracts of C. carbonum is relatively insensitive to HC-toxin
J H Ahn et al.
Molecular & general genetics : MGG, 260(5), 462-469 (1999-01-23)
HC-toxin is an epoxide-containing cyclic tetrapeptide that is a critical virulence determinant in the pathogenic interaction between the filamentous fungus Cochliobolus carbonum and maize. HC-toxin exerts a potent cytostatic effect on plant and animal cells by inhibiting histone deacetylase. The
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H7270-5MG | 04061832941219 |
| H7270-1MG | 04061826675175 |