H7270
HC toxin from Helminthosporium carbonum
lyophilized powder
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About This Item
Empirical Formula (Hill Notation):
C21H32N4O6
CAS Number:
Molecular Weight:
436.50
UNSPSC Code:
12352202
PubChem Substance ID:
MDL number:
Assay:
90-95% (TLC)
Form:
lyophilized powder
assay
90-95% (TLC)
form
lyophilized powder
storage temp.
2-8°C
SMILES string
CC1NC(=O)C(C)NC(=O)C2CCCN2C(=O)C(CCCCCC(=O)C3CO3)NC1=O
InChI
1S/C21H32N4O6/c1-12-18(27)22-13(2)19(28)24-14(7-4-3-5-9-16(26)17-11-31-17)21(30)25-10-6-8-15(25)20(29)23-12/h12-15,17H,3-11H2,1-2H3,(H,22,27)(H,23,29)(H,24,28)
InChI key
GNYCTMYOHGBSBI-UHFFFAOYSA-N
Biochem/physiol Actions
Cyclic tetrapeptide fungal toxin selectively toxic to plants with susceptible host genotype.
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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A N Nikolskaya et al.
Gene, 165(2), 207-211 (1995-11-20)
Race 1 of Cochliobolus carbonum (Cc) makes a cyclic tetrapeptide, HC-toxin, that is necessary for its virulence on certain genotypes of maize. The synthesis of HC-toxin is catalyzed by a 570-kDa multifunctional enzyme, HC-toxin synthetase (HTS). The gene encoding HTS
April R Robbins et al.
Cell cycle (Georgetown, Tex.), 4(5), 717-726 (2005-04-23)
The kinetochore, a multi-protein complex assembled on centromeric chromatin in mitosis, is essential for sister chromosome segregation. We show here that inhibition of histone deacetylation blocks mitotic progression at prometaphase in two human tumor cell lines by interfering with kinetochore
Pope, M.R., et al.
Biochemistry, 22, 3502-3502 (1983)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| H7270-1MG | 04061826675175 |
| H7270-5MG | 04061832941219 |