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Merck
CN

I0157

Ibudilast

≥99% (HPLC), Phosphodiesterase IV inhibitor, solid

Synonym(s):

2-Methyl-1-[2-(1-methylethyl)pyrazolo[1,5-a]pyridin-3-yl] 1-propanone, 3-Isobutyryl-2-isopropylpyrazolo[1,5-a]pyridine, KC-404

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About This Item

Empirical Formula (Hill Notation):
C14 H18 N2 O
CAS Number:
50847-11-5
Molecular Weight:
230.31
UNSPSC Code:
41106305
PubChem Substance ID:
24278482
NACRES:
NA.77
MDL number:
MFCD00864808
Assay:
≥99% (HPLC)
Form:
solid
Quality level:
200

Key Documents

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Product Name

Ibudilast, ≥99% (HPLC), solid

Quality Level

200

assay

≥99% (HPLC)

form

solid

color

white

solubility

DMSO: soluble 28 mg/mL, H2O: soluble 4.5 mg/mL

storage temp.

2-8°C

SMILES string

CC(C)C(=O)c1c(nn2ccccc12)C(C)C

InChI

1S/C14H18N2O/c1-9(2)13-12(14(17)10(3)4)11-7-5-6-8-16(11)15-13/h5-10H,1-4H3

InChI key

ZJVFLBOZORBYFE-UHFFFAOYSA-N

Gene Information

human ... PDE4A(5141), PDE4B(5142), PDE4C(5143), PDE4D(5144)

Related Categories

Biochem/physiol Actions

Phosphodiesterase IV (PDE4) inhbitor. Inhibits platelet aggregation. Anti-asthma drug.

Features and Benefits

This compound is a featured product for Cyclic Nucleotide research. Click here to discover more featured Cyclic Nucleotide products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

pictograms

Exclamation mark
GHS07

signalword

Warning

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000536625
0000536620
0000536625
0000536620
0000511227

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Saatviga Sudhahar et al.
Nature communications, 15(1), 5703-5703 (2024-07-09)
Explaining predictions for drug repositioning with biological knowledge graphs is a challenging problem. Graph completion methods using symbolic reasoning predict drug treatments and associated rules to generate evidence representing the therapeutic basis of the drug. Yet the vast amounts of
Jaclyn M Schwarz et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 33(3), 961-971 (2013-01-18)
Adolescence in humans represents a unique developmental time point associated with increased risk-taking behavior and experimentation with drugs of abuse. We hypothesized that exposure to drugs of abuse during adolescence may increase the risk of addiction in adulthood. To test
Keiko Sakuma et al.
Eye & contact lens, 35(5), 251-254 (2009-08-13)
To assess the influence of topical application of ibudilast for seasonal allergic conjunctivitis in patients wearing soft contact lenses (SCLs). There were 16 SCL wearers (32 eyes) with allergic conjunctivitis due to cedar pollen, who were studied from February to
P Rolan et al.
Expert opinion on pharmacotherapy, 10(17), 2897-2904 (2009-11-26)
Ibudilast is a relatively nonselective phosphodiesterase inhibitor which has been marketed for almost 20 years in Japan for treating asthma. More recently it has been found to have anti-inflammatory activity in both the peripheral immune system and in the CNS
Patrick M Beardsley et al.
European journal of pharmacology, 637(1-3), 102-108 (2010-04-20)
Stress and renewed contact with drug (a "slip") have been linked to persisting relapse of methamphetamine abuse. Human brain microglial activation has been linked with methamphetamine abuse, and inhibitors of glial cell activation, certain phosphodiesterase (PDE) inhibitors, and glial cell
View All Related Papers

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Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.

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Global Trade Item Number

SKUGTIN
I0157-10MG04061833271643
I0157-50MG04061833271650

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