N5636
3-Nitropropionic acid
≥97% (HPLC), powder or crystals, mitochondrial complex II inhibitor
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About This Item
Linear Formula:
O2N(CH2)2CO2H
CAS Number:
Molecular Weight:
119.08
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
208-003-0
MDL number:
Beilstein/REAXYS Number:
1759889
Product Name
3-Nitropropionic acid, ≥97%
biological source
synthetic
Quality Level
assay
≥97%
form
powder or crystals
color
white to light yellow
mp
68-70 °C (lit.)
solubility
alcohol: may be light yellow 100 mg/mL
storage temp.
2-8°C
SMILES string
OC(CC[N+]([O-])=O)=O
InChI
1S/C3H5NO4/c5-3(6)1-2-4(7)8/h1-2H2,(H,5,6)
InChI key
WBLZUCOIBUDNBV-UHFFFAOYSA-N
Application
3-Nitropropionic acid has been used:
- to generate multiple system atropy-parkinsoniam (MSA-P) model in rat to evaluate its effect on embryonic striatal and mesencephalic grafts
- to inject into the nigrostriatal dopaminergic pathway in rats in order to examine its specific effects on the dopamine system
- as succinate dehydrogenase (SDH) inhibitor for LUHMES neurons and cell lines
Biochem/physiol Actions
Administering 3-nitropropionic acid (3-NP) to the inner ear can stimulate sensorineural hearing loss. It serves as an irreversible inhibitor of mitochondrial complex II.
Excitotoxin shown to cause brain lesions similar to those of Huntington′s disease.
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signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 3 Oral
Storage Class
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
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Mouse Models of Dystonia
Animal Models of Movement Disorders (2005)
Dual loss of succinate dehydrogenase (SDH) and complex I activity is necessary to recapitulate the metabolic phenotype of SDH mutant tumors
Lorendeau D, et al.
Metabolic engineering, 43, 187-197 (2017)
No functional effects of embryonic neuronal grafts on motor deficits in a 3-nitropropionic acid rat model of advanced striatonigral degeneration (multiple system atrophy)
Waldner R, et al.
Neuroscience, 102(3), 581-592 (2001)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| N5636-10G | 04061834117124 |
| N5636-1G | 04061834117131 |