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P1851

PIPES

Name: PIPES
Brand: SIGMA

BioPerformance Certified, suitable for cell culture

Synonym(s):

1,4-Piperazinediethanesulfonic acid, Piperazine-1,4-bis(2-ethanesulfonic acid), Piperazine-N,N′-bis(2-ethanesulfonic acid)

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₈N₂O₆S₂

CAS Number:

5625-37-6

Molecular Weight:

302.37

UNSPSC Code:

12161700

NACRES:

NA.25

PubChem Substance ID:

24898249

EC Number:

227-057-6

Beilstein/REAXYS Number:

817713

MDL number:

MFCD00006159

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Quality Level

400

grade

BioPerformance Certified, Molecular Biology

form

crystalline powder

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin and Total Aerobic Microbial Count, tested

useful pH range

6.1-7.5

pKa (25 °C)

6.8

mp

>300 °C (lit.)

solubility

1 M NaOH: 20 + 80 mL g, clear, colorless, soluble

application(s)

diagnostic assay manufacturing

foreign activity

DNAse, Exonuclease; NICKase, Endonuclease; RNAse; Protease, none detected

SMILES string

OS(=O)(=O)CCN1CCN(CC1)CCS(O)(=O)=O

InChI

1S/C8H18N2O6S2/c11-17(12,13)7-5-9-1-2-10(4-3-9)6-8-18(14,15)16/h1-8H2,(H,11,12,13)(H,14,15,16)

InChI key

IHPYMWDTONKSCO-UHFFFAOYSA-N

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Related Categories

Biochemicals

Biological Buffers

High-Purity Biochemicals and Reagents

Chemistry & Biochemicals

Application

Sensitive Detection of Immunoglobulin G Stability Using in Real-Time Isothermal Differential Scanning Fluorimetry: Determinants of Protein Stability for Antibody-Based Therapeutics.: The use of PIPES buffer in this study was integral to maintaining the stability of immunoglobulin G during differential scanning fluorimetry. This method is crucial for evaluating the stability of antibody-based therapeutics (Moggridge et al., 2017).

Storage Class

13 - Non Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Hydrogen sulfide deactivates common nitrobenzofurazan-based fluorescent thiol labeling reagents.

Leticia A Montoya et al.

Analytical chemistry, 86(12), 6032-6039 (2014-05-24)

Sulfhydryl-containing compounds, including thiols and hydrogen sulfide (H2S), play important but differential roles in biological structure and function. One major challenge in separating the biological roles of thiols and H2S is developing tools to effectively separate the reactivity of these

Impurity in buffer substances mimics the effects of ATP on soluble 5'-nucleotidase.

M Le Hir

Enzyme, 45(4), 194-199 (1991-01-01)

An impurity, probably an anion, present in some batches of the buffer substances 4-(2-hydroxyethyl) piperazine-1-ethanesulfonic acid (HEPES), 2-morpholinoethane sulfonic acid (Mes) and piperazine-1,4-bis(2-ethane sulfonic acid (Pipes), activates the soluble 5'-nucleotidase from rat kidney. The affinity of the enzyme for 5'-IMP

Allelic expression mapping across cellular lineages to establish impact of non-coding SNPs.

Veronique Adoue et al.

Molecular systems biology, 10, 754-754 (2014-10-19)

Most complex disease-associated genetic variants are located in non-coding regions and are therefore thought to be regulatory in nature. Association mapping of differential allelic expression (AE) is a powerful method to identify SNPs with direct cis-regulatory impact (cis-rSNPs). We used

Low-intensity repetitive transcranial magnetic stimulation improves abnormal visual cortical circuit topography and upregulates BDNF in mice.

Kalina Makowiecki et al.

The Journal of neuroscience : the official journal of the Society for Neuroscience, 34(32), 10780-10792 (2014-08-08)

Repetitive transcranial magnetic stimulation (rTMS) is increasingly used as a treatment for neurological and psychiatric disorders. Although the induced field is focused on a target region during rTMS, adjacent areas also receive stimulation at a lower intensity and the contribution

Effects of carnosine and related compounds on the stability and morphology of erythrocytes from alcoholics.

V D Prokopieva et al.

Alcohol and alcoholism (Oxford, Oxfordshire), 35(1), 44-48 (2000-02-24)

The effects of carnosine and related compounds on erythrocytes from alcoholics were studied. In their presence, erythrocytes showed an increased ability to resist haemolysis and showed a more normal morphology, with carnosine and N-acetyl-carnosine being the most effective compounds. These

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Global Trade Item Number

SKU	GTIN
P1851-1KG	04061826757512
P1851-100G	04061834356837
P1851-25G	04061834356905
P1851-500G	04061834356912

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