P4147
pGlu-His-Gly acetate salt
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C13H17N5O5
CAS Number:
Molecular Weight:
323.30
UNSPSC Code:
12352200
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
OC(=O)CNC(=O)C(Cc1cnc[nH]1)NC(=O)C2CCC(=O)N2
Biochem/physiol Actions
Suppresses the cephalic phase rise in serum insulin and gastrin levels.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Inhibition of sham feeding-induced gastric secretion and serum hormonal responses by analogs of (pyro)Glu-His-Gly-OH.
A V Schally et al.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 170(3), 264-272 (1982-07-01)
J Kunert-Radek et al.
Biochemical and biophysical research communications, 181(2), 562-565 (1991-12-16)
The effects of thyrotropin releasing hormone (TRH) and of TRH-like tripeptide pGlu-His-Gly-OH (colon mitosis inhibitor, CMI) on spontaneous proliferation of murine splenocytes were investigated in vitro. The 3H-thymidine incorporation into splenocyte DNA was used as an index of proliferation. It
Jing Zhang et al.
Obesity (Silver Spring, Md.), 17(3), 474-480 (2008-12-06)
Gastric electrical stimulation (GES) has been proposed as a therapeutic option for obesity. However, its clinical efficacy is not proven, and its mechanisms remain largely unknown. To compare the peripheral and central neural and behavioral effects in rats of GES
M Pawlikowski et al.
Cytobios, 76(306-307), 151-155 (1993-01-01)
The effects of tripeptide colon mitosis inhibitor (CMI, pGlu-His-Gly-OH) on the proliferation of tumoral cells of dimethylhydrazine (DMH)-induced colonic cancers in rats were studied. Additionally, the effects of CMI on hyperplastic colonic crypts in DMH-treated rats and on normal colonic
Tamás Halmos et al.
Orvosi hetilap, 152(3), 83-91 (2011-01-06)
Regulatory role of the brain in energy expenditure, appetite, glucose metabolism, and central effects of insulin has been prominently studied. Certain neurons in the hypothalamus increase or decrease appetite via orexigenes and anorexigenes, regulating energy balance and food intake. Hypothalamus
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