P4147
pGlu-His-Gly acetate salt
≥97% (HPLC)
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About This Item
Empirical Formula (Hill Notation):
C13H17N5O5
CAS Number:
Molecular Weight:
323.30
UNSPSC Code:
12352200
MDL number:
assay
≥97% (HPLC)
storage temp.
−20°C
SMILES string
OC(=O)CNC(=O)C(Cc1cnc[nH]1)NC(=O)C2CCC(=O)N2
Biochem/physiol Actions
Suppresses the cephalic phase rise in serum insulin and gastrin levels.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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Tamás Halmos et al.
Orvosi hetilap, 152(3), 83-91 (2011-01-06)
Regulatory role of the brain in energy expenditure, appetite, glucose metabolism, and central effects of insulin has been prominently studied. Certain neurons in the hypothalamus increase or decrease appetite via orexigenes and anorexigenes, regulating energy balance and food intake. Hypothalamus
Zdeno Pirnik et al.
Peptides, 31(1), 139-144 (2009-10-13)
The hypothalamus plays an important role in food consumption, receiving information about energy balance via hormonal, metabolic, and neural inputs. Its neurons produce neuropeptides influencing energy balance. Especially important to regulation of food consumption are certain hypothalamic structures, including the
C H Görbitz et al.
Acta chemica Scandinavica (Copenhagen, Denmark : 1989), 47(10), 979-984 (1993-10-01)
The 1H spectrum of L-pyroglutamyl-L-histidylglycine in DMSO-d6 and 1H and 13C NMR spectra in D2O at pH 4.26 to 8.90 have been analysed. 3JHH vicinal coupling constants were used to determine rotamer populations by means of the Karplus equation. Viable
O Skraastad et al.
Carcinogenesis, 10(1), 79-82 (1989-01-01)
We have recently purified and identified a tripeptide (pGlu-His-GlyOH) in mouse intestinal extracts which reversibly inhibits normal colonic epithelial cell renewal in mice. We also found a similar response to a single injection of the peptide during bile-acid-induced hyperproliferation in
O Skraastad et al.
Virchows Archiv. B, Cell pathology including molecular pathology, 56(6), 393-396 (1989-01-01)
Extracts of mouse intestine contain a colonic epithelial mitosis inhibitor that has recently been purified and identified as a tripeptide (pGlu-His-GlyOH). In order to elucidate further the biological characteristics of this peptide, the effect of the tripeptide on cell proliferation
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