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P8013

Pargyline hydrochloride

Name: Pargyline hydrochloride
Brand: SIGMA

synthetic, 98% (TLC), MAO-B inhibitor, powder or crystals

Synonym(s):

N-Methyl-N-(2-propynyl)benzylamine hydrochloride, N-Methyl-N-propargylbenzylamine hydrochloride

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About This Item

Linear Formula:

C₆H₅CH₂N(CH₃)CH₂C≡CH·HCl

CAS Number:

306-07-0

Molecular Weight:

195.69

NACRES:

NA.77

PubChem Substance ID:

24278153

UNSPSC Code:

12352200

EC Number:

206-175-1

MDL number:

MFCD00012492

Beilstein/REAXYS Number:

3699487

Assay:

98% (TLC)

Form:

powder or crystals

Quality level:

200

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Properties

Product Name

Pargyline hydrochloride,

biological source

synthetic

Quality Level

200

assay

98% (TLC)

form

powder or crystals

mp

160-163 °C (lit.)

solubility

water: 50 mg/mL, clear, colorless to faintly yellow

storage temp.

−20°C

SMILES string

Cl[H].CN(CC#C)Cc1ccccc1

InChI

1S/C11H13N.ClH/c1-3-9-12(2)10-11-7-5-4-6-8-11;/h1,4-8H,9-10H2,2H3;1H

InChI key

BCXCABRDBBWWGY-UHFFFAOYSA-N

Gene Information

human ... MAOA(4128), MAOB(4129)

Description

Application

Pargyline hydrochloride has been used:

as a histone demethylase inhibitor to treat monocytes to investigate whether various inhibitors affect training
to maximize uptake into dopaminergic neurons (DA) neurons in experimental rats,
to study its effect on discolouration of medullary tissues of sclerotia of S. sclerotiorum

Biochem/physiol Actions

Pargyline hydrochloride acts as a histone demethylase inhibitor. It has antihypertensive action.

Selective MAO-B inhibitor.

pictograms

GHS06

signalword

Danger

hcodes

H301

pcodes

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Biochemical Pathway for the Formation of Abnormal Sclerotia of Sclerotinia sclerotiorum

Huang HC and Yeung JM

Plant Pathology, 11(1), 2-2 (2002)

Trained immunity or tolerance: opposing functional programs induced in human monocytes after engagement of various pattern recognition receptors

Ifrim DC, et al.

Clinical and Vaccine Immunology : CVI, 21(4), 534-545 (2014)

Resonant antidromic cortical circuit activation as a consequence of high-frequency subthalamic deep-brain stimulation

Li S, et al.

Journal of Neurophysiology, 98(6), 3525-3537 (2007)

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Global Trade Item Number

SKU	GTIN
P8013-5G	04061832948508
P8013-1G	04061834400769
P8013-500MG	04061832948492