R3772
Riluzole
Synonym(s):
2-Amino-6-(trifluoromethoxy)benzothiazole
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About This Item
Empirical Formula (Hill Notation):
C8H5F3N2OS
CAS Number:
Molecular Weight:
234.20
UNSPSC Code:
12352204
MDL number:
SMILES string
Nc1nc2ccc(OC(F)(F)F)cc2s1
InChI
1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
InChI key
FTALBRSUTCGOEG-UHFFFAOYSA-N
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Biochem/physiol Actions
Glutamate release inhibitor
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Charles Tzu-Chi Lee et al.
Journal of epidemiology, 23(1), 35-40 (2012-11-03)
Amyotrophic lateral sclerosis (ALS) is a rare disease in Taiwan; thus, estimation of ALS mortality is difficult. We evaluated factors associated with ALS survival in Taiwan. The study enrolled 1149 Taiwanese with a primary diagnosis of ALS during 1999-2008. Follow-up
Alessandra Cifra et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 19(2), 137-144 (2012-05-19)
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for which the only licensed treatment is riluzole. Although riluzole clinical efficacy is rather limited, its use has important implications for identifying those parameters that might improve its clinical
B C Cheah et al.
Current medicinal chemistry, 17(18), 1942-1199 (2010-04-10)
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the human motor system. Aetiological mechanisms implicated in the development of ALS have been linked to the glutamatergic neurotransmitter system, with destruction of motor neurons triggered through excessive activation
Rachna S Pandya et al.
Cellular and molecular life sciences : CMLS, 70(24), 4729-4745 (2013-07-19)
Amyotrophic lateral sclerosis (ALS) is a fatal chronic neurodegenerative disease whose hallmark is proteinaceous, ubiquitinated, cytoplasmic inclusions in motor neurons and surrounding cells. Multiple mechanisms proposed as responsible for ALS pathogenesis include dysfunction of protein degradation, glutamate excitotoxicity, mitochondrial dysfunction
Paul Grant et al.
Journal of child and adolescent psychopharmacology, 20(4), 309-315 (2010-09-03)
The antiglutamatergic drug riluzole (Rilutek) is presently being used off label in the treatment of psychiatric conditions in adult patients and, increasingly, in children. This article briefly reviews the pharmacology of this drug and its current investigative and clinical uses
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