R3772
Riluzole
Synonym(s):
2-Amino-6-(trifluoromethoxy)benzothiazole
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About This Item
Empirical Formula (Hill Notation):
C8H5F3N2OS
CAS Number:
Molecular Weight:
234.20
UNSPSC Code:
12352204
MDL number:
InChI key
FTALBRSUTCGOEG-UHFFFAOYSA-N
InChI
1S/C8H5F3N2OS/c9-8(10,11)14-4-1-2-5-6(3-4)15-7(12)13-5/h1-3H,(H2,12,13)
SMILES string
Nc1nc2ccc(OC(F)(F)F)cc2s1
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Biochem/physiol Actions
Glutamate release inhibitor
signalword
Danger
hcodes
pcodes
Hazard Classifications
Acute Tox. 2 Oral
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
wgk
WGK 3
ppe
Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges
Regulatory Information
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Charles Tzu-Chi Lee et al.
Journal of epidemiology, 23(1), 35-40 (2012-11-03)
Amyotrophic lateral sclerosis (ALS) is a rare disease in Taiwan; thus, estimation of ALS mortality is difficult. We evaluated factors associated with ALS survival in Taiwan. The study enrolled 1149 Taiwanese with a primary diagnosis of ALS during 1999-2008. Follow-up
B C Cheah et al.
Current medicinal chemistry, 17(18), 1942-1199 (2010-04-10)
Amyotrophic lateral sclerosis (ALS) is a universally fatal neurodegenerative disease of the human motor system. Aetiological mechanisms implicated in the development of ALS have been linked to the glutamatergic neurotransmitter system, with destruction of motor neurons triggered through excessive activation
Alessandra Cifra et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 19(2), 137-144 (2012-05-19)
Amyotrophic lateral sclerosis (Lou Gehrig's disease) is a devastating neurodegenerative disorder for which the only licensed treatment is riluzole. Although riluzole clinical efficacy is rather limited, its use has important implications for identifying those parameters that might improve its clinical
Gwen Schwartz et al.
Progress in brain research, 137, 177-190 (2002-11-21)
Traumatic spinal cord injury is a consequence of a primary mechanical insult and a sequence of progressive secondary pathophysiological events that confound efforts to mitigate neurological deficits. Pharmacotherapy aimed at reducing the secondary injury is limited by a narrow therapeutic
Mark C Bellingham
CNS neuroscience & therapeutics, 17(1), 4-31 (2010-03-20)
Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neurodegenerative disease of adults which preferentially attacks the neuromotor system. Riluzole has been used as the only approved treatment for amyotrophic lateral sclerosis since 1995, but its mechanism(s) of action in
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