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Merck
CN

S1198

Sumatriptan succinate

≥98% (HPLC), solid, 5-HT₁ receptor agonist

Synonym(s):

3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide succinate, GR-43175

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About This Item

Empirical Formula (Hill Notation):
C14H21N3O2S · C4H6O4
CAS Number:
103628-48-4
Molecular Weight:
413.49
UNSPSC Code:
12352200
PubChem Substance ID:
329824466
NACRES:
NA.77
MDL number:
MFCD00902856

Key Documents

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Product Name

Sumatriptan succinate, ≥98% (HPLC), solid

SMILES string

OC(=O)CCC(O)=O.CNS(=O)(=O)Cc1ccc2[nH]cc(CCN(C)C)c2c1

InChI key

PORMUFZNYQJOEI-UHFFFAOYSA-N

InChI

1S/C14H21N3O2S.C4H6O4/c1-15-20(18,19)10-11-4-5-14-13(8-11)12(9-16-14)6-7-17(2)3;5-3(6)1-2-4(7)8/h4-5,8-9,15-16H,6-7,10H2,1-3H3;1-2H2,(H,5,6)(H,7,8)

assay

≥98% (HPLC)

form

solid

color

white to beige

solubility

H2O: >20 mg/mL

originator

GlaxoSmithKline

Quality Level

100

Gene Information

human ... HTR1B(3351), HTR1D(3352)

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Biochem/physiol Actions

Sumatriptan succinate has the ability to constrict human cranial arteries. This 5-HT1 receptor agonist can be used to treat migraine.
Sumatriptan succinate is a 5-HT1 serotonin receptor agonist.

Features and Benefits

This compound was developed by GlaxoSmithKline. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazard
GHS08

signalword

Warning

Hazard Classifications

Aquatic Chronic 3 - Repr. 2

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
0000322181
0000322181
0000205788
0000205787

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Mucoadhesive bilayered patches for administration of sumatriptan succinate
Shidhaye SS, et al.
Aaps Pharmscitech, 9(3), 909-916 (2008)
Treatment of acute migraine with subcutaneous sumatriptan
Cady RK, et al.
JAMA : The Journal of the American Medical Association, 265(21), 2831-2835 (1991)
Tse-Ming Chou et al.
The journal of headache and pain, 23(1), 157-157 (2022-12-13)
To investigate specific brain regions and neural circuits that are responsible for migraine chronification. We established a mouse model of chronic migraine with intermittent injections of clinically-relevant dose of nitroglycerin (0.1 mg/kg for 9 days) and validated the model with cephalic and
Jeong Ju Seo et al.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 919-920, 38-42 (2013-02-16)
A sensitive and simple detection method coupling ultra-performance liquid chromatography with tandem mass spectrometry was developed and validated to analyze sumatriptan levels in human plasma. The plasma sample preparations for the analysis were based on liquid-liquid extraction with ethyl acetate
Y Sekino et al.
Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 24(12), 1083-e564-1083-e564 (2012-08-14)
Oral sumatriptan administration has been reported to delay gastric emptying after liquid meals. The aim of this study was to determine whether delayed gastric emptying is caused by enhanced gastric accommodation, impaired antral contractions, or both using ultrasonography. Ten healthy
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