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Merck
CN

S166

Saclofen

solid

Synonym(s):

β-(Aminomethyl)-4-chlorobenzeneethanesulfonic acid

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About This Item

Empirical Formula (Hill Notation):
C9H12ClNO3S
CAS Number:
125464-42-8
Molecular Weight:
249.71
NACRES:
NA.32
PubChem Substance ID:
329824485
UNSPSC Code:
51111800
MDL number:
MFCD00216817
Form:
solid
Quality level:
200

Key Documents

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form

solid

Quality Level

200

color

white

solubility

0.1 M NaOH: 20 mg/mL

SMILES string

NCC(CS(O)(=O)=O)c1ccc(Cl)cc1

InChI

1S/C9H12ClNO3S/c10-9-3-1-7(2-4-9)8(5-11)6-15(12,13)14/h1-4,8H,5-6,11H2,(H,12,13,14)

InChI key

JYLNVJYYQQXNEK-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568)
mouse ... GABBR1(54393), GABBR2(242425)
rat ... GABBR1(81657), GABBR2(83633)

Application

Saclofen has been used as a GABAB receptor antagonist to study the analgesic effect of repeated injections of oxycodone in rats.
Saclofen has been used to prevent the inhibitory action of oxytocin on capsaicin-induced glutamatergic spontaneous excitatory transmission in rat neurons.

Biochem/physiol Actions

Saclofen is the sulphonic analog of baclofen and is a selective GABAB receptor antagonist.
Saclofen might possess sympathetic nervous system-dependent anti-inflammatory action.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Certificates of Analysis (COA)

Lot/Batch Number
0000544335
0000544335
0000510273
0000510273
0000500585

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Eisuke Koya et al.
Neuropharmacology, 56 Suppl 1, 177-185 (2008-06-21)
Cue-induced drug-seeking in rodents progressively increases after withdrawal from cocaine, suggesting that cue-induced cocaine craving incubates over time. Here, we explored the role of the medial prefrontal cortex (mPFC, a brain area previously implicated in cue-induced cocaine seeking) in this
Molecular Mechanisms Underlying the Enhanced Analgesic Effect of Oxycodone Compared to Morphine in Chemotherapy-Induced Neuropathic Pain
Karine T
PLoS ONE (2014)
Antagonism at GABAB receptors by saclofen and related sulphonic analogues of baclofen and GABA
David I.B.Kerr
Neuroscience Letters (1989)
Faraz Mahdian Dehkordi et al.
The Korean journal of pain, 32(3), 160-167 (2019-07-02)
Pain is a complex mechanism which involves different systems, including the opioidergic and GABAergic systems. Due to the side effects of chemical analgesic agents, attention toward natural agents have been increased. Artemisinin is an herbal compound with widespread modern and
Gabriel S Bassi et al.
Naunyn-Schmiedeberg's archives of pharmacology, 389(8), 851-861 (2016-04-24)
Recent studies have demonstrated that the central nervous system controls inflammatory responses by activating complex efferent neuroimmune pathways. The present study was designed to evaluate the role that central gamma-aminobutyric acid type B (GABA-B) receptor plays in neutrophil migration in
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Global Trade Item Number

SKUGTIN
SAB5701894-100UL04065267678719
SAB5700317-100UL04065265172622
SAB5701958-100UL04065267679358
S166-5MG04061836912925

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