S5521
Suxibuzone
Synonym(s):
4-Butyl-4-(hydroxymethyl)-1,2-diphenyl-3,5-pyrazolidinedione hydrogen succinate (ester)
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About This Item
Empirical Formula (Hill Notation):
C24H26N2O6
CAS Number:
Molecular Weight:
438.47
UNSPSC Code:
12352202
PubChem Substance ID:
EC Number:
248-477-6
MDL number:
form
solid
SMILES string
CCCCC1(COC(=O)CCC(O)=O)C(=O)N(N(C1=O)c2ccccc2)c3ccccc3
InChI
1S/C24H26N2O6/c1-2-3-16-24(17-32-21(29)15-14-20(27)28)22(30)25(18-10-6-4-7-11-18)26(23(24)31)19-12-8-5-9-13-19/h4-13H,2-3,14-17H2,1H3,(H,27,28)
InChI key
ONWXNHPOAGOMTG-UHFFFAOYSA-N
Biochem/physiol Actions
A prodrug of phenylbutazone.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
Regulatory Information
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Basic and clinical studies of prodrugs of nonsteroidal anti-inflammatory drugs.
Y Mizushima
Pharmacology, 25 Suppl 1, 39-45 (1982-01-01)
M C Caturla et al.
Journal of chromatography, 581(1), 101-107 (1992-10-02)
A solid-phase extraction method was validated for the simultaneous high-performance liquid chromatographic determination of indomethacin, suxibuzone, phenylbutazone, oxyphenbutazone and their degradation products. Indomethacin was added as internal standard to plasma samples, which were then acidified with citrate buffer and passed
D Sabaté et al.
Equine veterinary journal, 41(7), 700-705 (2009-11-26)
In horses, it has been demonstrated that suxibuzone (SBZ) has a lower gastric ulcerogenic effect than phenylbutazone (PBZ). However, no field trials have been reported comparing the efficacy of the drugs in alleviating lameness. To compare the therapeutic effect of