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S6764

[pGlu6, Pro9]-Substance P fragment 6-11

≥95% (HPLC)

Synonym(s):

Septide, pGlu-Phe-Phe-Pro-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C39H53N7O7S
CAS Number:
79775-19-2
Molecular Weight:
763.95
UNSPSC Code:
12352200
MDL number:
MFCD00076800
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assay

≥95% (HPLC)

storage temp.

−20°C

Biochem/physiol Actions

A potent and selective NK-1 tachykinin receptor agonist.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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Certificates of Analysis (COA)

Lot/Batch Number
128F07562

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John M T Chu et al.
Neuropharmacology, 61(8), 1389-1398 (2011-09-13)
Neurokinin one (NK1) receptor is Substance P (SP) receptor and it is abundantly distributed in the basal ganglia. Growing evidences were shown on their possible roles in the pathogenesis and treatment of Parkinson's disease (PD). NK1 receptor is a kind
F Y Chang et al.
Journal of gastroenterology and hepatology, 14(1), 39-45 (1999-02-24)
Natural neurokinins (NK) and their specific receptor agonists, including substance P (SP), neurokinin A (NKA), neurokinin B (NKB), septide, [NIe10]-NKA4-10 and senktide, were used to assess whether they could activate established NK receptors in rat gastrointestinal tract and central nervous
Heiko U De Schepper et al.
Regulatory peptides, 130(3), 105-115 (2005-06-07)
Tachykinins are important mediators in neuromuscular signalling but have not been thoroughly characterised in the mouse gut. We investigated the participation of tachykinin receptors in contractility of circular muscle strips of the mouse ileum. Electrical field stimulation (EFS) of excitatory
Clementine Schouteden et al.
The Journal of cell biology, 210(1), 35-44 (2015-07-01)
Cilia are cellular projections that perform sensory and motile functions. A key ciliary subdomain is the transition zone, which lies between basal body and axoneme. Previous work in Caenorhabditis elegans identified two ciliopathy-associated protein complexes or modules that direct assembly
E Cellier et al.
British journal of pharmacology, 127(3), 717-728 (1999-07-13)
1. Effects of two tachykinin NK1 receptor selective agonists (septide and [Sar9, Met(O2)11]SP) were compared on the increases in mean arterial pressure (MAP), heart rate (HR) and motor behaviour following intracerebroventricular (i.c.v.) administration in unanaesthetized rat, and on the vascular
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