S6764
[pGlu6, Pro9]-Substance P fragment 6-11
≥95% (HPLC)
Synonym(s):
Septide, pGlu-Phe-Phe-Pro-Leu-Met-NH2
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About This Item
Empirical Formula (Hill Notation):
C39H53N7O7S
CAS Number:
Molecular Weight:
763.95
UNSPSC Code:
12352200
MDL number:
assay
≥95% (HPLC)
storage temp.
−20°C
Biochem/physiol Actions
A potent and selective NK-1 tachykinin receptor agonist.
Storage Class
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Regulatory Information
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John M T Chu et al.
Neuropharmacology, 61(8), 1389-1398 (2011-09-13)
Neurokinin one (NK1) receptor is Substance P (SP) receptor and it is abundantly distributed in the basal ganglia. Growing evidences were shown on their possible roles in the pathogenesis and treatment of Parkinson's disease (PD). NK1 receptor is a kind
F Y Chang et al.
Journal of gastroenterology and hepatology, 14(1), 39-45 (1999-02-24)
Natural neurokinins (NK) and their specific receptor agonists, including substance P (SP), neurokinin A (NKA), neurokinin B (NKB), septide, [NIe10]-NKA4-10 and senktide, were used to assess whether they could activate established NK receptors in rat gastrointestinal tract and central nervous
Functional characterisation of tachykinin receptors in the circular muscle layer of the mouse ileum.
Heiko U De Schepper et al.
Regulatory peptides, 130(3), 105-115 (2005-06-07)
Tachykinins are important mediators in neuromuscular signalling but have not been thoroughly characterised in the mouse gut. We investigated the participation of tachykinin receptors in contractility of circular muscle strips of the mouse ileum. Electrical field stimulation (EFS) of excitatory