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S8385

[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11

≥95% (HPLC)

Synonym(s):

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C43H61N9O9S
CAS Number:
77128-69-9
Molecular Weight:
880.06
UNSPSC Code:
12352200
PubChem Substance ID:
329824602
MDL number:
MFCD00133835
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assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O

InChI

1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)

InChI key

IEEBRBMEXFNVKU-UHFFFAOYSA-N

Gene Information

human ... TAC1(6863)

Biochem/physiol Actions

Substance P analog which is resistant to attack by a substance P degrading enzyme.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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J M Barnes et al.
Pharmacology, biochemistry, and behavior, 37(4), 839-841 (1990-12-01)
The effect on forebrain catecholamine- and indoleamine-related neurochemical levels was investigated following stimulation of the rat ventral tegmental area with the substance P analogue, DiMe-C7. DiMe-C7 (6.0 micrograms) induced a marked hyperactivity in rats with maximal response between 15 and
J Mao et al.
Brain research, 574(1-2), 157-163 (1992-03-06)
The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching induced by i.t. substance P (SP), bombesin (BBS), strychnine (STR), and kainic acid (KA). CGRP alone (5.25, 10.5 and
R Mathison et al.
Brain research, 644(2), 251-256 (1994-05-02)
The effects of intravenous injection of prostaglandin E2 (PGE2), substance P (SP) and a metabolically stable SP analogue, [pGlu5,Me-Phe8,Sar9]-SP (5-11) on plasma extravasation of albumin in the rat after blockade of prostaglandin synthesis with indomethacin or chemical sympathectomy with guanethidine
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