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Merck
CN

S8385

[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11

≥95% (HPLC)

Synonym(s):

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C43H61N9O9S
CAS Number:
77128-69-9
Molecular Weight:
880.06
UNSPSC Code:
12352200
PubChem Substance ID:
329824602
MDL number:
MFCD00133835

Key Documents

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InChI

1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O

InChI key

IEEBRBMEXFNVKU-UHFFFAOYSA-N

assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

Gene Information

human ... TAC1(6863)

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Biochem/physiol Actions

Substance P analog which is resistant to attack by a substance P degrading enzyme.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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J L Cornish et al.
Neuroscience letters, 176(2), 142-146 (1994-08-01)
Central dopaminergic systems have been implicated in the regulation of blood pressure. We examined the effect on blood pressure of electrical or chemical stimulation of the rat brain ventral tegmental area (VTA) which is the region of origin of the
J M Barnes et al.
Pharmacology, biochemistry, and behavior, 37(4), 839-841 (1990-12-01)
The effect on forebrain catecholamine- and indoleamine-related neurochemical levels was investigated following stimulation of the rat ventral tegmental area with the substance P analogue, DiMe-C7. DiMe-C7 (6.0 micrograms) induced a marked hyperactivity in rats with maximal response between 15 and
J Mao et al.
Brain research, 574(1-2), 157-163 (1992-03-06)
The present study examined the effects of intrathecal (i.t.) injection of calcitonin gene-related peptide (CGRP) on caudally directed biting and scratching induced by i.t. substance P (SP), bombesin (BBS), strychnine (STR), and kainic acid (KA). CGRP alone (5.25, 10.5 and
R Mathison et al.
Brain research, 644(2), 251-256 (1994-05-02)
The effects of intravenous injection of prostaglandin E2 (PGE2), substance P (SP) and a metabolically stable SP analogue, [pGlu5,Me-Phe8,Sar9]-SP (5-11) on plasma extravasation of albumin in the rat after blockade of prostaglandin synthesis with indomethacin or chemical sympathectomy with guanethidine
M van den Buuse et al.
Clinical and experimental pharmacology & physiology, 25(7-8), 624-626 (1998-07-23)
1. Stimulation of the mesolimbic dopamine system, by micro-injection of the substance P analogue [pGlu5,MePhe8,Sar9] substance P (DiMe-C7) into the ventral tegmental area induced a prolonged increase in blood pressure and circulating levels of vasopressin. 2. In the present study
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