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Merck
CN

S8385

[pGlu5, N-Me-Phe8, Sar9]-Substance P Fragment 5-11

≥95% (HPLC)

Synonym(s):

pGlu-Gln-Phe-N-Methyl-Phe-Sar-Leu-Met-NH2

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About This Item

Empirical Formula (Hill Notation):
C43H61N9O9S
CAS Number:
77128-69-9
Molecular Weight:
880.06
UNSPSC Code:
12352200
PubChem Substance ID:
329824602
MDL number:
MFCD00133835

Key Documents

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InChI

1S/C43H61N9O9S/c1-26(2)22-32(41(59)48-29(38(45)56)20-21-62-5)47-37(55)25-51(3)43(61)34(24-28-14-10-7-11-15-28)52(4)42(60)33(23-27-12-8-6-9-13-27)50-40(58)31(16-18-35(44)53)49-39(57)30-17-19-36(54)46-30/h6-15,26,29-34H,16-25H2,1-5H3,(H2,44,53)(H2,45,56)(H,46,54)(H,47,55)(H,48,59)(H,49,57)(H,50,58)

SMILES string

CSCCC(NC(=O)C(CC(C)C)NC(=O)CN(C)C(=O)C(Cc1ccccc1)N(C)C(=O)C(Cc2ccccc2)NC(=O)C(CCC(N)=O)NC(=O)C3CCC(=O)N3)C(N)=O

InChI key

IEEBRBMEXFNVKU-UHFFFAOYSA-N

assay

≥95% (HPLC)

UniProt accession no.

P20366

storage temp.

−20°C

Gene Information

human ... TAC1(6863)

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Biochem/physiol Actions

Substance P analog which is resistant to attack by a substance P degrading enzyme.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Regulatory Information

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R Mathison et al.
European journal of pharmacology, 240(2-3), 163-168 (1993-08-24)
The effect of inhibiting nitric oxide synthase (N omega-nitro-L-arginine) on plasma extravasation induced by intravenously administered substance P, [pGlu5,Me-Phe8,Sar9]substance P-(5-11) or prostaglandin E2 was examined. Control rats were more responsive than diabetic rats to both substance P and [pGlu5,Me-Phe8,Sar9]-substance P-(5-11).
H Yang et al.
The American journal of physiology, 272(5 Pt 1), G987-G993 (1997-05-01)
Neurons that contain substance P (SP) and thyrotropin-releasing hormone (TRH) in medullary midline raphe nuclei project to the dorsal vagal complex (DVC). The modulatory role of SP on basal gastric acid secretion (GAS) and TRH on DVC-induced stimulation of GAS
P J Elliott et al.
Pharmacology, biochemistry, and behavior, 37(2), 329-333 (1990-10-01)
The stable substance P analog, DiMeC7, increases spontaneous locomotor activity after infusion into the lateral ventricles or median raphe nucleus (MRN). The elevated locomotion observed after intracerebroventricular (ICV) infusion of DiMeC7 was attenuated, but not blocked, by bilateral 6-hydroxydopamine (6OHDA)
N Altier et al.
Brain research, 628(1-2), 279-285 (1993-11-19)
Experiments were designed to examine the analgesic effects of SP injected into the ventral tegmental area (VTA). Rats received bilateral intra-VTA infusions of 3.0 micrograms/0.5 microliter/side of the SP analogue, DiMe-C7, or the vehicle, either immediately prior to or 25
J L Cornish et al.
Neuroscience, 81(1), 69-78 (1997-09-23)
The aim of the present study was to further characterize the involvement of the mesolimbic dopamine system in central blood pressure regulation, with particular emphasis on the interaction of this system with the effects of circulating vasopressin. In conscious rats
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